Abstract
BACKGROUND AND OBJECTIVE: Ellipsoid zone (EZ) reflectivity on optical coherence tomography (OCT) is affected by the orientation of the scanning beam. The authors sought to determine how directional reflectivity changes in dry age-related macular degeneration (AMD). PATIENTS AND METHODS: Retrospective image analysis included 17 control and 20 dry AMD subjects. Directional OCT (D-OCT) was performed using multiple displaced pupil entrance positions. EZ pixel values and apparent incidence angles were measured. RESULTS: EZ reflectivity decreased in off-axis scans in controls (P < .001), AMD areas between drusen (P < .001), and AMD areas overlying drusen (P < .001). The magnitude of decrement in EZ reflectivity was significantly higher when incidence angles exceeded 10° in controls than in AMD areas between drusen (P = .024). CONCLUSION: EZ reflectivity in dry AMD may vary by incident angle of light less than in controls, possibly indicating alteration of photoreceptor orientation or integrity.
Original language | English (US) |
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Pages (from-to) | 145-152 |
Number of pages | 8 |
Journal | Ophthalmic Surgery Lasers and Imaging Retina |
Volume | 52 |
Issue number | 3 |
DOIs | |
State | Published - 2021 |
ASJC Scopus subject areas
- Surgery
- Ophthalmology