@article{dc242cb588e84d549b42ef057bdc3516,
title = "Directional reflectivity of the ellipsoid zone in dry age-related macular degeneration",
abstract = "BACKGROUND AND OBJECTIVE: Ellipsoid zone (EZ) reflectivity on optical coherence tomography (OCT) is affected by the orientation of the scanning beam. The authors sought to determine how directional reflectivity changes in dry age-related macular degeneration (AMD). PATIENTS AND METHODS: Retrospective image analysis included 17 control and 20 dry AMD subjects. Directional OCT (D-OCT) was performed using multiple displaced pupil entrance positions. EZ pixel values and apparent incidence angles were measured. RESULTS: EZ reflectivity decreased in off-axis scans in controls (P < .001), AMD areas between drusen (P < .001), and AMD areas overlying drusen (P < .001). The magnitude of decrement in EZ reflectivity was significantly higher when incidence angles exceeded 10° in controls than in AMD areas between drusen (P = .024). CONCLUSION: EZ reflectivity in dry AMD may vary by incident angle of light less than in controls, possibly indicating alteration of photoreceptor orientation or integrity.",
author = "Griffin, {Shane M.} and Yali Jia and Johnson, {Alicia J.} and Antony, {Bhavna J.} and {Richard McDonald}, H. and Johnson, {Robert N.} and Lujan, {Brandon J.}",
note = "Funding Information: Originally submitted July 20, 2020. Revision received November 23, 2020. Accepted for publication January 26, 2021. Dr. Lujan has received grants and personal fees from Genentech/Roche; personal fees from RegenexBio, Lineage/BioTime/Cell Cure, Novartis, Regeneron; and non-financial support from Topcon outside the submitted work. He also has a patent issued for Directional OCT. Dr. Jia is supported by funding from an NIH grant and receives patent royalties and research support from Optovue. Dr. Antony is employed by IBM Research. The remaining authors report no relevant financial disclosures. The authors would like to thank Amy Laird, PhD, for her statistical support. Address correspondence to Brandon J. Lujan, MD, Oregon Health & Science University Casey Eye Institute, 3303 S Bond Ave., Building 1, 11th Floor, Portland, OR 97239; email: lujanb@ohsu.edu. doi: 10.3928/23258160-20210302-05 Publisher Copyright: {\textcopyright} 2021 Slack Incorporated. All rights reserved.",
year = "2021",
doi = "10.3928/23258160-20210302-05",
language = "English (US)",
volume = "52",
pages = "145--152",
journal = "Ophthalmic Surgery and Lasers",
issn = "2325-8160",
publisher = "Slack Incorporated",
number = "3",
}