Disciform Degeneration of the Macula: II. Pathogenesis

Evangelos S. Gragoudas, Suresh R. Chandra, Ephraim Friedman, Michael L. Klein, Michael Van Buskirk

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Of 84 patients with unilateral disciform macular degeneration, 36 were followed up for one to four years (average, 22 months). The fellow eye in 13 cases developed disciform lesions during that follow-up period. A significantly greater number of drusen were found in the fellow eyes of patients with unilateral disciform macular degeneration than in the eyes of a comparable control group of patients (P≪.001). Furthermore, the eyes with unilateral disciform macular degeneration that developed disciform lesions in the other eye were characterized as a group by a significantly larger number of drusen than those that did not. We postulate that drusen are precursors of disciform macular degeneration in fellow eyes and are probably manifestations of the same exudative process.

Original languageEnglish (US)
Pages (from-to)755-757
Number of pages3
JournalArchives of ophthalmology
Issue number5
StatePublished - May 1976
Externally publishedYes


  • Drusen
  • disciform degeneration of macula
  • disciform lesion of macula
  • macula
  • macula degeneration
  • senile disciform degeneration

ASJC Scopus subject areas

  • Ophthalmology


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