Distal convoluted tubule

Arohan R. Subramanya, David H. Ellison

Research output: Contribution to journalArticlepeer-review

144 Scopus citations


The distal convoluted tubule is the nephron segment that lies immediately downstream of the macula densa. Although short in length, the distal convoluted tubule plays a critical role in sodium, potassium, and divalent cation homeostasis. Recent genetic and physiologic studies have greatly expanded our understanding of how the distal convoluted tubule regulates these processes at the molecular level. This article provides an update on the distal convoluted tubule, highlighting concepts and pathophysiology relevant to clinical practice.

Original languageEnglish (US)
Pages (from-to)2147-2163
Number of pages17
JournalClinical Journal of the American Society of Nephrology
Issue number12
StatePublished - 2014

ASJC Scopus subject areas

  • Epidemiology
  • Critical Care and Intensive Care Medicine
  • Nephrology
  • Transplantation


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