Distinctive profile of sudden cardiac arrest in middle-aged vs. older adults: A community-based study

Amit Noheria, Carmen Teodorescu, Audrey Uy-Evanado, Kyndaron Reinier, Ronald Mariani, Karen Gunson, Jonathan Jui, Sumeet S. Chugh

Research output: Contribution to journalArticlepeer-review

37 Scopus citations


Background While sudden cardiac arrest (SCA) rates increase with age, middle-aged adults (35-59 years) may comprise a significant proportion of SCA cases in the community (30-40%). However, there is a lack of studies evaluating SCA risk factors specifically associated with this age-group of the population. Methods Using prospective multiple-source surveillance methodology we identified cases of SCA ≥ 35 years in the ongoing Oregon Sudden Unexpected Death Study (Portland, Oregon metropolitan area, population ≈ 1,000,000). Out-of-hospital SCA cases, aged 35-59 years were compared to older SCA cases (≥ 60 years) in a comprehensive analysis of clinical profile of SCA. Results The middle-aged (n = 753) compared to older (n = 1251) cases were more likely to be male, obese, have sleep apnea and seizure disorder (all p ≤ 0.001); and were less likely to have a history of hypertension, diabetes mellitus, known coronary artery disease, congestive heart failure and syncope (all p < 0.01). In multivariable analyses the middle-aged group had higher likelihood of male sex (O.R. 1.67, 95% C.I. 1.29-2.18), obesity (2.20, 1.52-3.19), sleep apnea (2.30, 1.44-3.68) and seizure disorder (2.69, 1.64-4.42); and lower rates of known coronary artery disease (0.57, 0.43-0.74) and congestive heart failure (0.35, 0.25-0.48). Conclusions SCA in the middle-aged adult was distinguishable from older subjects by higher rates of obesity, sleep apnea and seizure disorder; and lower prevalence of traditional clinical risk markers. With the growing epidemic of obesity, these findings have implications for SCA burden; and suggest the need for a clinical and investigational focus on SCA prediction and prevention in the middle-aged adult, that is distinct from older adults.

Original languageEnglish (US)
Pages (from-to)3495-3499
Number of pages5
JournalInternational Journal of Cardiology
Issue number4
StatePublished - Oct 9 2013


  • Community
  • Coronary artery disease
  • Middle-age
  • Obesity
  • Sudden-death

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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