Distribution of ionic sulfate, lithium, and bromide across the sheep placenta

K. L. Thornburg, N. D. Binder, J. J. Faber

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Salts of sulfate, lithium, and bromine were injected or infused intravenously into ewes in the last trimester of gestation. Ewes and fetuses had indwelling catheters, most fetuses were nephrectomized. Concentrations were measured in paired maternal and fetal samples over periods of 4-14 days. Maternal excretion of sulfate was too rapid to permit near equilibration of fetal and maternal plasma concentrations; the results, however, did not support the existence of a large potential difference across the exchange barrier. The concentrations of Li+ (given by continuous infusion) and 82Br- in maternal plasma did not change rapidly. The concentrations of these tracers in fetal plasma rose until they were nearly equal to the maternal plasma concentrations. Steady-state transplacental potentials, calculated by use of the Nernst equation, were 5.2 ± 2.0 (SEM) mV (n = 26) for Li+ and -2.2 ± 0.8 (SEM) mV (n = 10) for Br-. Nernst potentials calculated from previously measured maternal and fetal plasma concentrations of Na+, K+, Mg2+, and Cl- were +0.4, +3.6, +0.5, and -1.4 mV. The authors concluded that, of the total potential difference of about -50 mV (fetus negative) between the fetal lamb and the ewe, only a few mV are dropped across the placental exchange barrier.

Original languageEnglish (US)
Pages (from-to)C58-C65
JournalAmerican Journal of Physiology - Cell Physiology
Issue number1
StatePublished - 1979
Externally publishedYes

ASJC Scopus subject areas

  • Physiology
  • Cell Biology


Dive into the research topics of 'Distribution of ionic sulfate, lithium, and bromide across the sheep placenta'. Together they form a unique fingerprint.

Cite this