Diuretic action of the narcotic antagonist oxilorphan

John G. Nutt, Donald R. Jasinski

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


The narcotic antagonists oxilorphan and d,l-cyclazocine increased urinary output without affecting fluid intake in 10 subjects on ad libitum fluids. In 8 water-deprived subjects oxilorphan increased urinary output and decreased urine osmolality without significantly altering blood pressure, creatinine clearance, electrolyte excretion, or solute excretion. Three of 4 water-loaded subjects excreted a water load slightly more efficiently after the drug. Ten milligrams o f naloxone had no diuretic effect itself and did not antagonize the diuretic effect o f oxilorphan. Five units o f vasopressin prevented the drug-induced diuresis. These results suggest that the diuretic effect is an agonistic action of oxilorphan produced by inhibition of antidiuretic hormone (ADH) release.

Original languageEnglish (US)
Pages (from-to)361-367
Number of pages7
JournalClinical pharmacology and therapeutics
Issue number4
StatePublished - Apr 1974
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)


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