TY - JOUR
T1 - Diverse roles for hyaluronan and hyaluronan receptors in the developing and adult nervous system
AU - Peters, Alec
AU - Sherman, Larry S.
N1 - Funding Information:
Funding: This work was supported by the Congressionally Directed Medical Research Programs, Grant/Award Number: MS160144; National Multiple Sclerosis Society, Grant/Award Numbers: PP-1801-29683, RG 4843A5/1; NIH Grant/Award Number R24 NS104161-01; and NIH Office of the Director, Grant/Award Number: P51 OD011092.
Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2020/9/1
Y1 - 2020/9/1
N2 - Hyaluronic acid (HA) plays a vital role in the extracellular matrix of neural tissues. Originally thought to hydrate tissues and provide mechanical support, it is now clear that HA is also a complex signaling molecule that can regulate cell processes in the developing and adult nervous systems. Signaling properties are determined by molecular weight, bound proteins, and signal transduction through specific receptors. HA signaling regulates processes such as proliferation, differentiation, migration, and process extension in a variety of cell types including neural stem cells, neurons, astrocytes, microglia, and oligodendrocyte progenitors. The synthesis and catabolism of HA and the expression of HA receptors are altered in disease and influence neuroinflammation and disease pathogenesis. This review discusses the roles of HA, its synthesis and breakdown, as well as receptor expression in neurodevelopment, nervous system function and disease.
AB - Hyaluronic acid (HA) plays a vital role in the extracellular matrix of neural tissues. Originally thought to hydrate tissues and provide mechanical support, it is now clear that HA is also a complex signaling molecule that can regulate cell processes in the developing and adult nervous systems. Signaling properties are determined by molecular weight, bound proteins, and signal transduction through specific receptors. HA signaling regulates processes such as proliferation, differentiation, migration, and process extension in a variety of cell types including neural stem cells, neurons, astrocytes, microglia, and oligodendrocyte progenitors. The synthesis and catabolism of HA and the expression of HA receptors are altered in disease and influence neuroinflammation and disease pathogenesis. This review discusses the roles of HA, its synthesis and breakdown, as well as receptor expression in neurodevelopment, nervous system function and disease.
KW - Extracellular matrix
KW - Hyaluronan
KW - Hyaluronic acid
KW - Nervous system
KW - Neurodevelopment
KW - Neurogenesis
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U2 - 10.3390/ijms21175988
DO - 10.3390/ijms21175988
M3 - Review article
C2 - 32825309
AN - SCOPUS:85089655767
SN - 1661-6596
VL - 21
SP - 1
EP - 21
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
IS - 17
M1 - 5988
ER -