TY - JOUR
T1 - DNA methylation patterns associated with konzo in Sub-Saharan Africa
AU - Kocher, Kristen
AU - Bhattacharya, Surajit
AU - Bramble, Matthew S.
AU - Okitundu-Luwa, Daniel
AU - Ngoyi, Dieudonne Mumba
AU - Tshala-Katumbay, Desire
AU - Vilain, Eric
N1 - Publisher Copyright:
© 2022, The Author(s).
PY - 2022/12
Y1 - 2022/12
N2 - Konzo, a disease characterized by sudden, irreversible spastic paraparesis, affecting up to 10% of the population in some regions of Sub-Saharan Africa during outbreaks, is strongly associated with dietary exposure to cyanogenic bitter cassava. The molecular mechanisms underlying the development of konzo remain largely unknown. Here, through an analysis of 16 individuals with konzo and matched healthy controls from the same outbreak zones, we identified 117 differentially methylated loci involved in numerous biological processes that may identify cyanogenic-sensitive regions of the genome, providing the first study of epigenomic alterations associated with a clinical phenotype of konzo.
AB - Konzo, a disease characterized by sudden, irreversible spastic paraparesis, affecting up to 10% of the population in some regions of Sub-Saharan Africa during outbreaks, is strongly associated with dietary exposure to cyanogenic bitter cassava. The molecular mechanisms underlying the development of konzo remain largely unknown. Here, through an analysis of 16 individuals with konzo and matched healthy controls from the same outbreak zones, we identified 117 differentially methylated loci involved in numerous biological processes that may identify cyanogenic-sensitive regions of the genome, providing the first study of epigenomic alterations associated with a clinical phenotype of konzo.
KW - Cassava
KW - Cyanide
KW - DNA methylation
KW - Epigenetics
KW - Konzo
KW - Sub-Saharan Africa
UR - http://www.scopus.com/inward/record.url?scp=85144298997&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85144298997&partnerID=8YFLogxK
U2 - 10.1186/s13148-022-01372-x
DO - 10.1186/s13148-022-01372-x
M3 - Article
C2 - 36536449
AN - SCOPUS:85144298997
SN - 1868-7075
VL - 14
JO - Clinical epigenetics
JF - Clinical epigenetics
IS - 1
M1 - 179
ER -