DNA sequence of two closely linked human leukocyte interferon genes

Richard M. Lawn; John Adelman; Thomas J. Dull; Mitchell Gross; David Goeddel; Axel Ullrich

doi:10.1126/science.6165082

DNA sequence of two closely linked human leukocyte interferon genes

Richard M. Lawn, John Adelman, Thomas J. Dull, Mitchell Gross, David Goeddel, Axel Ullrich

Research output: Contribution to journal › Article › peer-review

73 Scopus citations

Abstract

A single recombinant lambda bacteriophage isolated from a human genome library contains two closely related human interferon genes of the leukocyte or α type. The two genes are separated by 12 kilobase pairs and are oriented in the same direction with respect to transcription. Comparisons of the DNA sequences of these two genes and interferon complementary DNA clones indicate that the two interferon genes lack intervening sequences.

Original language	English (US)
Pages (from-to)	1159-1162
Number of pages	4
Journal	Science
Volume	212
Issue number	4499
DOIs	https://doi.org/10.1126/science.6165082
State	Published - 1981
Externally published	Yes

ASJC Scopus subject areas

General

Access to Document

10.1126/science.6165082

Cite this

@article{fc6a3b7ce7be4faebca327df6f84df9e,

title = "DNA sequence of two closely linked human leukocyte interferon genes",

abstract = "A single recombinant lambda bacteriophage isolated from a human genome library contains two closely related human interferon genes of the leukocyte or α type. The two genes are separated by 12 kilobase pairs and are oriented in the same direction with respect to transcription. Comparisons of the DNA sequences of these two genes and interferon complementary DNA clones indicate that the two interferon genes lack intervening sequences.",

author = "Lawn, {Richard M.} and John Adelman and Dull, {Thomas J.} and Mitchell Gross and David Goeddel and Axel Ullrich",

year = "1981",

doi = "10.1126/science.6165082",

language = "English (US)",

volume = "212",

pages = "1159--1162",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "4499",

}

TY - JOUR

T1 - DNA sequence of two closely linked human leukocyte interferon genes

AU - Lawn, Richard M.

AU - Adelman, John

AU - Dull, Thomas J.

AU - Gross, Mitchell

AU - Goeddel, David

AU - Ullrich, Axel

PY - 1981

Y1 - 1981

N2 - A single recombinant lambda bacteriophage isolated from a human genome library contains two closely related human interferon genes of the leukocyte or α type. The two genes are separated by 12 kilobase pairs and are oriented in the same direction with respect to transcription. Comparisons of the DNA sequences of these two genes and interferon complementary DNA clones indicate that the two interferon genes lack intervening sequences.

AB - A single recombinant lambda bacteriophage isolated from a human genome library contains two closely related human interferon genes of the leukocyte or α type. The two genes are separated by 12 kilobase pairs and are oriented in the same direction with respect to transcription. Comparisons of the DNA sequences of these two genes and interferon complementary DNA clones indicate that the two interferon genes lack intervening sequences.

UR - http://www.scopus.com/inward/record.url?scp=0019829494&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019829494&partnerID=8YFLogxK

U2 - 10.1126/science.6165082

DO - 10.1126/science.6165082

M3 - Article

C2 - 6165082

AN - SCOPUS:0019829494

SN - 0036-8075

VL - 212

SP - 1159

EP - 1162

JO - Science

JF - Science

IS - 4499

ER -

DNA sequence of two closely linked human leukocyte interferon genes

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this