DNA sequence of two closely linked human leukocyte interferon genes

Richard M. Lawn, John Adelman, Thomas J. Dull, Mitchell Gross, David Goeddel, Axel Ullrich

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


A single recombinant lambda bacteriophage isolated from a human genome library contains two closely related human interferon genes of the leukocyte or α type. The two genes are separated by 12 kilobase pairs and are oriented in the same direction with respect to transcription. Comparisons of the DNA sequences of these two genes and interferon complementary DNA clones indicate that the two interferon genes lack intervening sequences.

Original languageEnglish (US)
Pages (from-to)1159-1162
Number of pages4
Issue number4499
StatePublished - 1981
Externally publishedYes

ASJC Scopus subject areas

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