Does APOE genotype modify the relations between serum lipid and erythrocyte omega-3 fatty acid levels?

William S. Harris, James V. Pottala, Dawn L. Thiselton, Stephen A. Varvel, Alison M. Baedke, Thomas D. Dayspring, G. Russell Warnick, Joseph P. McConnell

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Earlier reports indicated that patients with the apolipoprotein APOE ε4 allele responded to fish oil supplementation with a rise in serum low-density lipoprotein cholesterol (LDL-C) compared to ε3 homozygotes. In this study, we used clinical laboratory data to test the hypothesis that the cross-sectional relation between RBC omega-3 fatty acid status (the Omega-3 Index) and LDL-C was modified by APOE genotype. Data from 136,701 patients were available to compare lipid biomarker levels across Omega-3 Index categories associated with heart disease risk in all APOE genotypes. We found no adverse interactions between APOE genotype and the Omega-3 Index for LDL-C, LDL particle number, apoB, HDL-C, or triglycerides. However, we did find evidence that ε2 homozygotes lack an association between omega-3 status and LDL-C, apoB, and LDL particle number. In summary, we found no evidence for a deleterious relationship between lipid biomarkers and the Omega-3 Index by APOE genotype.

Original languageEnglish (US)
Pages (from-to)526-532
Number of pages7
JournalJournal of Cardiovascular Translational Research
Issue number5
StatePublished - Jul 2014
Externally publishedYes


  • APOE genotype
  • APOE4
  • Lipids
  • Low-density lipoproteins
  • Omega-3 fatty acids
  • Triglycerides
  • apoB

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Pharmaceutical Science
  • Cardiology and Cardiovascular Medicine
  • Genetics(clinical)


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