Does HIV cause salivary gland disease?

M. Schiodt, D. Greenspan, J. A. Levy, J. A. Nelson, D. Chernoff, H. Hollander, J. S. Greenspan

Research output: Contribution to journalArticlepeer-review

46 Scopus citations


HIV-associated salivary gland disease (HIV-SGD) is characterized by enlargement of the major salivary glands and/or xerostomia. HIV does not appear to play a direct role in this disease since it was detected by immunohistochemistry in only occasional lymphocytes in labial salivary glands in two out of six patients; it was not found in the salivary gland epithelial cells. Moreover, HIV was not found in any of 21 saliva samples from seven patients. We conclude that HIV-SGD is not caused by direct infection of the salivary glands with HIV.

Original languageEnglish (US)
Pages (from-to)819-822
Number of pages4
Issue number12
StatePublished - 1989
Externally publishedYes


  • AIDS
  • HIV
  • Sjogren's syndrome
  • saliva
  • salivary gland disease

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases


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