Donor Unrestricted T Cells: Linking innate and adaptive immunity

Shogo Soma; Deborah A. Lewinsohn; David M. Lewinsohn

doi:10.1016/j.vaccine.2021.10.044

Donor Unrestricted T Cells: Linking innate and adaptive immunity

Shogo Soma, Deborah A. Lewinsohn, David M. Lewinsohn

Research output: Contribution to journal › Article › peer-review

Abstract

Donor Unrestricted T Cells (DURTs) are characterized by their use of antigen presentation molecules that are often invariant. As these cells recognize diverse mycobacterial antigens, often found in BCG, these cells have the potential to either serve as targets for vaccination, or as a means to enable the induction of traditional T and B cell immunity. Here, we will review specific DURT family members, and their relationship to BCG.

Original language	English (US)
Pages (from-to)	7295-7299
Number of pages	5
Journal	Vaccine
Volume	39
Issue number	50
DOIs	https://doi.org/10.1016/j.vaccine.2021.10.044
State	Published - Dec 8 2021

Keywords

BCG
CD1
Donor Unrestricted T cell
Gamma Delta
HLA-E
MR1

ASJC Scopus subject areas

Molecular Medicine
Immunology and Microbiology(all)
veterinary(all)
Public Health, Environmental and Occupational Health
Infectious Diseases

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10.1016/j.vaccine.2021.10.044

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title = "Donor Unrestricted T Cells: Linking innate and adaptive immunity",

abstract = "Donor Unrestricted T Cells (DURTs) are characterized by their use of antigen presentation molecules that are often invariant. As these cells recognize diverse mycobacterial antigens, often found in BCG, these cells have the potential to either serve as targets for vaccination, or as a means to enable the induction of traditional T and B cell immunity. Here, we will review specific DURT family members, and their relationship to BCG.",

keywords = "BCG, CD1, Donor Unrestricted T cell, Gamma Delta, HLA-E, MR1",

author = "Shogo Soma and Lewinsohn, {Deborah A.} and Lewinsohn, {David M.}",

note = "Funding Information: For Dr. Soma: NIH NIAID AI134790 For Dr. Deborah Lewinsohn: NIH NIAID AI129980 For Dr. David Lewinsohn: VA Merit Review 2I01BX000533; NIH NIAID AI134790; NIH NIAID AI129980; NIH NIAIDBAA-NIAID-NIH AI201700104; Bill & Melinda Gates Foundation INV-01899. Publisher Copyright: {\textcopyright} 2021",

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month = dec,

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doi = "10.1016/j.vaccine.2021.10.044",

language = "English (US)",

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AU - Lewinsohn, Deborah A.

AU - Lewinsohn, David M.

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AB - Donor Unrestricted T Cells (DURTs) are characterized by their use of antigen presentation molecules that are often invariant. As these cells recognize diverse mycobacterial antigens, often found in BCG, these cells have the potential to either serve as targets for vaccination, or as a means to enable the induction of traditional T and B cell immunity. Here, we will review specific DURT family members, and their relationship to BCG.

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KW - CD1

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KW - Gamma Delta

KW - HLA-E

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Donor Unrestricted T Cells: Linking innate and adaptive immunity

Abstract

Keywords

ASJC Scopus subject areas

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