Abstract
Traditional phase-resolved Doppler optical coherence tomography (DOCT) has been reported to have potential for characterizing local fluid flow within a microporous scaffold. In this work, we apply Doppler optical microangiography (DOMAG), a new imaging technique developed by combining optical microangiography (OMAG) with a phase-resolved method, for improved assessment of local fluid flow and its derived parameters, shear stress, and interconnectivity, within highly scattering porous constructs. Compared with DOCT, we demonstrate a dramatic improvement of DOMAG in quantifying flow-related properties within scaffolds in situ for functional tissue engineering.
Original language | English (US) |
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Article number | 050504 |
Journal | Journal of biomedical optics |
Volume | 14 |
Issue number | 5 |
DOIs | |
State | Published - 2009 |
Keywords
- Fluid flow
- Optical coherence tomography
- Optical microangiography
- Porous scaffold
- Shear stress
- Tissue engineering
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Biomaterials
- Atomic and Molecular Physics, and Optics
- Biomedical Engineering