Abstract
Experiments in hippocampal area CA1 suggest that long-term potentiation could be associated with spine addition and enlargement, and long-term depression (LTD) with spine shrinkage and loss. Is this a general principle of synaptic plasticity? We used two-photon microscopy to measure dendritic spines in rat cerebellar Purkinje cells. Neither local synaptic induction of LTD nor global chemical induction of LTD changed spine number or size. Conversely, a manipulation that evoked persistent dendritic spine retraction did not alter parallel fiber-evoked excitatory postsynaptic currents.
Original language | English (US) |
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Pages (from-to) | 546-548 |
Number of pages | 3 |
Journal | Nature Neuroscience |
Volume | 10 |
Issue number | 5 |
DOIs | |
State | Published - May 2007 |
Externally published | Yes |
ASJC Scopus subject areas
- General Neuroscience