Down regulation in B lymphocytes: low dose signals

Marilyn Baltz, M. B. Rittenberg

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Picogram quantities of dinitrophenylated (DNP) dextran, a thymus‐inde‐pendent antigen or lipopolysaccharide, a B cell mitogen, signal down B lymphocytes to unresponsiveness. Down signals were detected by a decision test in which signaled lymphocytes were allowed one hour to react to an immunogenic pulse of DNP‐dextran. Depletion of T cells or macrophages did not interfere with the generation of down signals. The signaling can proceed entirely at 4 °C and its negative effect is transitory. Down signals which could be detected after 15 min at 37°C were reversed by 60 min. It is suggested that down regulation by low dose antigenic signals provides a means of distinguishing background noise from true antigenic stimuli.

Original languageEnglish (US)
Pages (from-to)218-222
Number of pages5
JournalEuropean Journal of Immunology
Issue number4
StatePublished - Apr 1977

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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