@inproceedings{380891961ad64183b3d7220ff3f736b3,
title = "Drug delivery with microsecond laser pulses into gelatin",
abstract = "Photoacoustic drug delivery is a technique for localized drug delivery by laser-induced hydrodynamic pressure following cavitation bubble expansion and collapse. Photoacoustic drug delivery was investigated on gelatin-based thrombus models with planar and cylindrical geometries by use of one microsecond laser pulses. Solutions of a hydrophobic dye in mineral oil permitted monitoring of delivered colored oil into clear gelatin-based thrombus models. Cavitation bubble development and photoacoustic drug delivery were visualized with flash photography. This study demonstrated that cavitation is the governing mechanism for photoacoustic drug delivery, and the deepest penetration of colored oil in gels followed the bubble collapse. Spatial distribution measurements revealed that colored oil could be driven a few millimeters into the gels in both axial and radial directions, and the penetration was less than 500 µm when the gelatin structure was not fractured.",
keywords = "Ablation, Cavitation bubble, Laser thrombolysis, Localized drug delivery, Photoacoustic transients",
author = "Shangguan, {Han Qun} and Casperson, {Lee W.} and Alan Shearin and Gregory, {Kenton W.} and Prahl, {Scott A.}",
note = "Publisher Copyright: {\textcopyright} 1997 Optical Society of America.; Topical Meeting on Therapeutic Laser Applications, TLA 1998 ; Conference date: 08-03-1998",
year = "1998",
language = "English (US)",
series = "Optics InfoBase Conference Papers",
publisher = "Optica Publishing Group (formerly OSA)",
pages = "287--297",
booktitle = "Therapeutic Laser Applications, TLA 1998",
}