Drugs Used in Circadian Sleep-Wake Rhythm Disturbances

Helen J. Burgess, Jonathan S. Emens

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations


This article focuses on melatonin and other melatonin receptor agonists, and specifically their circadian phase shifting and sleep-enhancing properties. The circadian system and circadian rhythm sleep-wake disorders are briefly reviewed, followed by a summary of the circadian phase shifting, sleep-enhancing properties, and possible safety concerns associated with melatonin and other melatonin receptor agonists. The recommended use of melatonin, including dose and timing, in the latest American Academy of Sleep Medicine Clinical Practice Guidelines for the treatment of intrinsic circadian rhythm disorders is also reviewed. Lastly, the practical aspects of treatment and consideration of clinical treatment outcomes are discussed.

Original languageEnglish (US)
Pages (from-to)231-241
Number of pages11
JournalSleep Medicine Clinics
Issue number2
StatePublished - Jun 2018


  • Advance
  • Agonist
  • Circadian
  • Delay
  • Melatonin
  • Shift
  • Sleep

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Clinical Psychology
  • Clinical Neurology
  • Psychiatry and Mental health


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