TY - JOUR
T1 - Dual-transmitter neurons
T2 - Functional implications of co-release and co-transmission
AU - Vaaga, Christopher E.
AU - Borisovska, Maria
AU - Westbrook, Gary L.
N1 - Funding Information:
We thank all the members of the Westbrook lab for helpful discussion. We also thank Lori Vaskalis for help with illustrations. This work was supported by NIH Grants NS26464 and MH46613 to GLW; as well as a Tartar Trust Fellowship, ARCS Scholarship, and National Science Foundation Graduate Research Fellowship ( DGE0925180 ) to CEV.
PY - 2014/12
Y1 - 2014/12
N2 - Co-transmission, the ability of a neuron to release multiple transmitters, has long been recognized in selected circuits. However, the release of multiple primary neurotransmitters from a single neuron is only beginning to be appreciated. Here we consider recent examples of co-transmission as well as co-release. -the packaging of multiple neurotransmitters into a single vesicle. The properties associated with each mode of release greatly enhance the possible action of such neurons within circuits. The functional importance of dual- (or multi-) transmitter neurons extends beyond actions on postsynaptic receptors, due in part to differential spatial and temporal profiles of each neurotransmitter. Recent evidence also suggests that the dual-transmitter phenotype can be dynamically regulated during development and following injury or disease.
AB - Co-transmission, the ability of a neuron to release multiple transmitters, has long been recognized in selected circuits. However, the release of multiple primary neurotransmitters from a single neuron is only beginning to be appreciated. Here we consider recent examples of co-transmission as well as co-release. -the packaging of multiple neurotransmitters into a single vesicle. The properties associated with each mode of release greatly enhance the possible action of such neurons within circuits. The functional importance of dual- (or multi-) transmitter neurons extends beyond actions on postsynaptic receptors, due in part to differential spatial and temporal profiles of each neurotransmitter. Recent evidence also suggests that the dual-transmitter phenotype can be dynamically regulated during development and following injury or disease.
UR - http://www.scopus.com/inward/record.url?scp=84900027698&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84900027698&partnerID=8YFLogxK
U2 - 10.1016/j.conb.2014.04.010
DO - 10.1016/j.conb.2014.04.010
M3 - Review article
C2 - 24816154
AN - SCOPUS:84900027698
SN - 0959-4388
VL - 29
SP - 25
EP - 32
JO - Current Opinion in Neurobiology
JF - Current Opinion in Neurobiology
ER -