Dual-transmitter neurons: Functional implications of co-release and co-transmission

Christopher E. Vaaga, Maria Borisovska, Gary L. Westbrook

Research output: Contribution to journalReview articlepeer-review

102 Scopus citations


Co-transmission, the ability of a neuron to release multiple transmitters, has long been recognized in selected circuits. However, the release of multiple primary neurotransmitters from a single neuron is only beginning to be appreciated. Here we consider recent examples of co-transmission as well as co-release. -the packaging of multiple neurotransmitters into a single vesicle. The properties associated with each mode of release greatly enhance the possible action of such neurons within circuits. The functional importance of dual- (or multi-) transmitter neurons extends beyond actions on postsynaptic receptors, due in part to differential spatial and temporal profiles of each neurotransmitter. Recent evidence also suggests that the dual-transmitter phenotype can be dynamically regulated during development and following injury or disease.

Original languageEnglish (US)
Pages (from-to)25-32
Number of pages8
JournalCurrent Opinion in Neurobiology
StatePublished - Dec 2014

ASJC Scopus subject areas

  • Neuroscience(all)


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