Dynamic-contrast-enhanced-MRI with extravasating contrast reagent: Rat cerebral glioma blood volume determination

Xin Li; William D. Rooney; Csanád G. Várallyay; Seymur Gahramanov; Leslie L. Muldoon; James A. Goodman; Ian J. Tagge; Audrey H. Selzer; Martin M. Pike; Edward A. Neuwelt; Charles S. Springer

doi:10.1016/j.jmr.2010.07.004

Dynamic-contrast-enhanced-MRI with extravasating contrast reagent: Rat cerebral glioma blood volume determination

Xin Li, William D. Rooney, Csanád G. Várallyay, Seymur Gahramanov, Leslie L. Muldoon, James A. Goodman, Ian J. Tagge, Audrey H. Selzer, Martin M. Pike, Edward A. Neuwelt, Charles S. Springer

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44 Scopus citations

Abstract

The accurate mapping of the tumor blood volume (TBV) fraction (v _b) is a highly desired imaging biometric goal. It is commonly thought that achieving this is difficult, if not impossible, when small molecule contrast reagents (CRs) are used for the T₁-weighted (Dynamic-Contrast-Enhanced) DCE-MRI technique. This is because angiogenic malignant tumor vessels allow facile CR extravasation. Here, a three-site equilibrium water exchange model is applied to DCE-MRI data from the cerebrally-implanted rat brain U87 glioma, a tumor exhibiting rapid CR extravasation. Analyses of segments of the (and the entire) DCE data time-course with this "shutter-speed" pharmacokinetic model, which admits finite water exchange kinetics, allow TBV estimation from the first-pass segment. Pairwise parameter determinances were tested with grid searches of 2D parametric error surfaces. Tumor blood volume (v_b), as well as v_e (the extracellular, extravascular space volume fraction), and K^trans (a CR extravasation rate measure) parametric maps are presented. The role of the Patlak Plot in DCE-MRI is also considered.

Original language	English (US)
Pages (from-to)	190-199
Number of pages	10
Journal	Journal of Magnetic Resonance
Volume	206
Issue number	2
DOIs	https://doi.org/10.1016/j.jmr.2010.07.004
State	Published - Oct 2010

Keywords

DCE-MRI
Patlak Plot
Pharmacokinetics
Shutter-speed
Water exchange

ASJC Scopus subject areas

Biophysics
Biochemistry
Nuclear and High Energy Physics
Condensed Matter Physics

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10.1016/j.jmr.2010.07.004

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Li, X., Rooney, W. D., Várallyay, C. G., Gahramanov, S., Muldoon, L. L., Goodman, J. A., Tagge, I. J., Selzer, A. H., Pike, M. M., Neuwelt, E. A., & Springer, C. S. (2010). Dynamic-contrast-enhanced-MRI with extravasating contrast reagent: Rat cerebral glioma blood volume determination. Journal of Magnetic Resonance, 206(2), 190-199. https://doi.org/10.1016/j.jmr.2010.07.004

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abstract = "The accurate mapping of the tumor blood volume (TBV) fraction (v b) is a highly desired imaging biometric goal. It is commonly thought that achieving this is difficult, if not impossible, when small molecule contrast reagents (CRs) are used for the T1-weighted (Dynamic-Contrast-Enhanced) DCE-MRI technique. This is because angiogenic malignant tumor vessels allow facile CR extravasation. Here, a three-site equilibrium water exchange model is applied to DCE-MRI data from the cerebrally-implanted rat brain U87 glioma, a tumor exhibiting rapid CR extravasation. Analyses of segments of the (and the entire) DCE data time-course with this {"}shutter-speed{"} pharmacokinetic model, which admits finite water exchange kinetics, allow TBV estimation from the first-pass segment. Pairwise parameter determinances were tested with grid searches of 2D parametric error surfaces. Tumor blood volume (vb), as well as ve (the extracellular, extravascular space volume fraction), and Ktrans (a CR extravasation rate measure) parametric maps are presented. The role of the Patlak Plot in DCE-MRI is also considered.",

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Dynamic-contrast-enhanced-MRI with extravasating contrast reagent: Rat cerebral glioma blood volume determination

Abstract

Keywords

ASJC Scopus subject areas

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