Dynamic-contrast-enhanced-MRI with extravasating contrast reagent: Rat cerebral glioma blood volume determination

Xin Li, William D. Rooney, Csanád G. Várallyay, Seymur Gahramanov, Leslie L. Muldoon, James A. Goodman, Ian J. Tagge, Audrey H. Selzer, Martin M. Pike, Edward A. Neuwelt, Charles S. Springer

Research output: Contribution to journalArticlepeer-review

44 Scopus citations


The accurate mapping of the tumor blood volume (TBV) fraction (v b) is a highly desired imaging biometric goal. It is commonly thought that achieving this is difficult, if not impossible, when small molecule contrast reagents (CRs) are used for the T1-weighted (Dynamic-Contrast-Enhanced) DCE-MRI technique. This is because angiogenic malignant tumor vessels allow facile CR extravasation. Here, a three-site equilibrium water exchange model is applied to DCE-MRI data from the cerebrally-implanted rat brain U87 glioma, a tumor exhibiting rapid CR extravasation. Analyses of segments of the (and the entire) DCE data time-course with this "shutter-speed" pharmacokinetic model, which admits finite water exchange kinetics, allow TBV estimation from the first-pass segment. Pairwise parameter determinances were tested with grid searches of 2D parametric error surfaces. Tumor blood volume (vb), as well as ve (the extracellular, extravascular space volume fraction), and Ktrans (a CR extravasation rate measure) parametric maps are presented. The role of the Patlak Plot in DCE-MRI is also considered.

Original languageEnglish (US)
Pages (from-to)190-199
Number of pages10
JournalJournal of Magnetic Resonance
Issue number2
StatePublished - Oct 2010


  • Patlak Plot
  • Pharmacokinetics
  • Shutter-speed
  • Water exchange

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Nuclear and High Energy Physics
  • Condensed Matter Physics


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