Early biocompatibility of crosslinked and non-crosslinked biologic meshes in a porcine model of ventral hernia repair

L. Melman, E. D. Jenkins, N. A. Hamilton, L. C. Bender, M. D. Brodt, C. R. Deeken, S. C. Greco, M. M. Frisella, B. D. Matthews

Research output: Contribution to journalArticlepeer-review

93 Scopus citations


Purpose: Biologic meshes have unique physical properties as a result of manufacturing techniques such as decellularization, crosslinking, and sterilization. The purpose of this study is to directly compare the biocompatibility profiles of five different biologic meshes, AlloDerm® (non-crosslinked human dermal matrix), PeriGuard® (crosslinked bovine pericardium), Permacol® (crosslinked porcine dermal matrix), Strattice® (non-crosslinked porcine dermal matrix), and Veritas® (non-crosslinked bovine pericardium), using a porcine model of ventral hernia repair. Methods: Full-thickness fascial defects were created in 20 Yucatan minipigs and repaired with the retromuscular placement of biologic mesh 3 weeks later. Animals were euthanized at 1 month and the repair sites were subjected to tensile testing and histologic analysis. Samples of unimplanted (de novo) meshes and native porcine abdominal wall were also analyzed for their mechanical properties. Results: There were no significant differences in the biomechanical characteristics between any of the mesh-repaired sites at 1 month postimplantation or between the native porcine abdominal wall without implanted mesh and the mesh-repaired sites (P > 0.05 for all comparisons). Histologically, non-crosslinked materials exhibited greater cellular infiltration, extracellular matrix (ECM) deposition, and neovascularization compared to crosslinked meshes. Conclusions: While crosslinking differentiates biologic meshes with regard to cellular infiltration, ECM deposition, scaffold degradation, and neovascularization, the integrity and strength of the repair site at 1 month is not significantly impacted by crosslinking or by the de novo strength/stiffness of the mesh.

Original languageEnglish (US)
Pages (from-to)157-164
Number of pages8
Issue number2
StatePublished - Apr 2011
Externally publishedYes


  • Biologic mesh
  • Crosslinking
  • Remodeling
  • Tensile strength
  • Ventral hernia repair

ASJC Scopus subject areas

  • Surgery


Dive into the research topics of 'Early biocompatibility of crosslinked and non-crosslinked biologic meshes in a porcine model of ventral hernia repair'. Together they form a unique fingerprint.

Cite this