TY - JOUR
T1 - Early-Onset Pauciarticular Juvenile Rheumatoid Arthritis
T2 - A Histopathologic Study
AU - Merriam, John C.
AU - Chylack, Leo T.
AU - Albert, Daniel M.
PY - 1983/7
Y1 - 1983/7
N2 - A young girl with early-onset pauciarticular juvenile rheumatoid arthritis suffered from recurrent severe bilateral iridocyclitis. Despite intensive medical therapy, she gradually lost all useful vision and ultimately required bilateral enucleation at the age of 10 years for control of pain and photophobia. Histopathologic study of the eyes revealed in the iris and ciliary body a dense inflammatory infiltrate composed principally of plasma cells, as well as angle closure, a dense cyclitic membrane, retinal detachment, cystoid macula, and optic atrophy. Immunoperoxidase stains showed little immunoglobulin within or around the plasma cells within the ciliary body, although strong reactions for IgG and κ- and λ-light chains were seen in other parts of the eyes.
AB - A young girl with early-onset pauciarticular juvenile rheumatoid arthritis suffered from recurrent severe bilateral iridocyclitis. Despite intensive medical therapy, she gradually lost all useful vision and ultimately required bilateral enucleation at the age of 10 years for control of pain and photophobia. Histopathologic study of the eyes revealed in the iris and ciliary body a dense inflammatory infiltrate composed principally of plasma cells, as well as angle closure, a dense cyclitic membrane, retinal detachment, cystoid macula, and optic atrophy. Immunoperoxidase stains showed little immunoglobulin within or around the plasma cells within the ciliary body, although strong reactions for IgG and κ- and λ-light chains were seen in other parts of the eyes.
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U2 - 10.1001/archopht.1983.01040020087015
DO - 10.1001/archopht.1983.01040020087015
M3 - Article
C2 - 6347150
AN - SCOPUS:0020593931
SN - 0003-9950
VL - 101
SP - 1085
EP - 1092
JO - Archives of ophthalmology
JF - Archives of ophthalmology
IS - 7
ER -