Effect of abscess milieu on bactericidal activity of LY146032 against staphylococci

R. E. Bryant; J. A. Mazza; E. M. Gardner

doi:10.1007/BF02018206

Effect of abscess milieu on bactericidal activity of LY146032 against staphylococci

R. E. Bryant, J. A. Mazza, E. M. Gardner

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

The antistaphylococcal activity of LY146032 was tested in human pus in vitro and in a murine abscess model in vivo. The drug was not degraded by pus containingΒlactamase and had equally good or better activity than nafcillin or vancomycin againstStaphylococcus aureus or Staphylococcus epidermidisin vitro and in vivo. Its activity was slightly enhanced when used in combination with rifampin and tobramycin.

Original language	English (US)
Pages (from-to)	186-188
Number of pages	3
Journal	European Journal of Clinical Microbiology
Volume	6
Issue number	2
DOIs	https://doi.org/10.1007/BF02018206
State	Published - Apr 1987
Externally published	Yes

ASJC Scopus subject areas

Microbiology
Microbiology (medical)

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10.1007/BF02018206

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title = "Effect of abscess milieu on bactericidal activity of LY146032 against staphylococci",

abstract = "The antistaphylococcal activity of LY146032 was tested in human pus in vitro and in a murine abscess model in vivo. The drug was not degraded by pus containingΒlactamase and had equally good or better activity than nafcillin or vancomycin againstStaphylococcus aureus or Staphylococcus epidermidisin vitro and in vivo. Its activity was slightly enhanced when used in combination with rifampin and tobramycin.",

author = "Bryant, {R. E.} and Mazza, {J. A.} and Gardner, {E. M.}",

year = "1987",

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AU - Mazza, J. A.

AU - Gardner, E. M.

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AB - The antistaphylococcal activity of LY146032 was tested in human pus in vitro and in a murine abscess model in vivo. The drug was not degraded by pus containingΒlactamase and had equally good or better activity than nafcillin or vancomycin againstStaphylococcus aureus or Staphylococcus epidermidisin vitro and in vivo. Its activity was slightly enhanced when used in combination with rifampin and tobramycin.

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Effect of abscess milieu on bactericidal activity of LY146032 against staphylococci

Abstract

ASJC Scopus subject areas

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