TY - JOUR
T1 - Effect of age on circulating immunoreactive and bioactive parathyroid hormone levels in women
AU - Forero, Martha Susana
AU - Klein, Robert F.
AU - Nissenson, Robert A.
AU - Nelson, Karen
AU - Iii, Hunter Heath
AU - Arnaud, Claude D.
AU - Riggs, Lawrence B.
PY - 1987/10
Y1 - 1987/10
N2 - Although levels of serum immunoreactive parathyroid hormone (iPTH) increase with age in women, this could be caused by retention of non‐biologically active PTH fragments by the aging kidney. In 102 normal women, aged 30 to 89 yr, serum iPTH increased with age by 58% (r = 0.33, p < 0.001) with antiserum GP‐1M (which has midmolecule specificity) and 43% (r = 0.32, p < 0.001) with antiserum CH‐12M (which may have whole molecule specificity); urinary cAMP/GFR excretion increased by 29% (r = 0.22, p < 0.05). The results of these assays were validated by comparison with serum levels of biologically active PTH (BioPTH) in immunoextracts of serum followed by renal adenylate cyclase assay in a selected subgroup of 25 of the women. Serum BioPTH correlated with serum iPTH assessed by antiserum GP‐1M (r = 0.48, p < 0.05) and antiserum CH‐12M (r = 0.48, p < 0.05) but not with urinary cAMP. The data are consistent with an increase of parathyroid function with aging: clearly, we do not find decreased parathyroid function as would be expected if age‐related bone loss was not mediated, in part, by PTH.
AB - Although levels of serum immunoreactive parathyroid hormone (iPTH) increase with age in women, this could be caused by retention of non‐biologically active PTH fragments by the aging kidney. In 102 normal women, aged 30 to 89 yr, serum iPTH increased with age by 58% (r = 0.33, p < 0.001) with antiserum GP‐1M (which has midmolecule specificity) and 43% (r = 0.32, p < 0.001) with antiserum CH‐12M (which may have whole molecule specificity); urinary cAMP/GFR excretion increased by 29% (r = 0.22, p < 0.05). The results of these assays were validated by comparison with serum levels of biologically active PTH (BioPTH) in immunoextracts of serum followed by renal adenylate cyclase assay in a selected subgroup of 25 of the women. Serum BioPTH correlated with serum iPTH assessed by antiserum GP‐1M (r = 0.48, p < 0.05) and antiserum CH‐12M (r = 0.48, p < 0.05) but not with urinary cAMP. The data are consistent with an increase of parathyroid function with aging: clearly, we do not find decreased parathyroid function as would be expected if age‐related bone loss was not mediated, in part, by PTH.
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U2 - 10.1002/jbmr.5650020502
DO - 10.1002/jbmr.5650020502
M3 - Article
C2 - 3455620
AN - SCOPUS:0023427801
SN - 0884-0431
VL - 2
SP - 363
EP - 366
JO - Journal of Bone and Mineral Research
JF - Journal of Bone and Mineral Research
IS - 5
ER -