Effect of brimonidine 0.5% on intraocular pressure spikes following 360° argon laser trabeculoplasty

A. L. Robin, R. David, L. Shani, H. Barnebey, C. E. Clevenger, T. J. Zimmerman, G. Nardin, S. B. Hersh, J. C. Morrison, G. L. Spaeth, L. J. Katz, H. F. Perell, L. I. Siegel, R. A. Lewis, J. C. Henry, A. L. Coleman, D. A. Lee, M. C. Stiles, M. S. Passo

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


Background and Objective: Brimonidine tartrate 0.5%, a topical alpha2-adrenergic agonist, was administered before and after argon laser trabeculoplasty (ALT) to evaluate its efficacy against postoperative intraocular pressure (IOP) spikes. Patients and Methods: Two randomized, double-masked, vehicle-controlled investigations evaluated four treatment regimens in 471 patients undergoing ALT for glaucoma or ocular hypertension. The combined results are presented. Results: IOP elevations ≥ 10 mmHg occured in 1% (1/122) of the patients who received brimonidine before and after ALT; in 2% (2/119) of those receiving brimonidine before and vehicle after; in 1% (1/114) of those receiving vehicle before and brimonidine after; and in 23% (27/116) of those receiving vehicle before and after (P < .001). Conclusion: The brimonidine regimens were generally effective and well-tolerated ocularly and systemically.

Original languageEnglish (US)
Pages (from-to)404-409
Number of pages6
JournalOphthalmic Surgery and Lasers
Issue number5
StatePublished - 1995
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology


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