TY - JOUR
T1 - Effect of capsaicin on potassium conductance and electromotility of the guinea pig outer hair cell
AU - Wu, T.
AU - Song, L.
AU - Shi, X.
AU - Jiang, Z.
AU - Santos-Sacchi, J.
AU - Nuttall, A. L.
PY - 2011/2
Y1 - 2011/2
N2 - Capsaicin, the classic activator of TRPV-1 channels in primary sensory neurons, evokes nociception. Interestingly, auditory reception is also modulated by this chemical, possibly by direct actions on outer hair cells (OHCs). Surprisingly, we find two novel actions of capsaicin unrelated to TRPV-1 channels, which likely contribute to its auditory effects in vivo. First, capsaicin is a potent blocker of OHC K conductances (IK and IK,n). Second, capsaicin substantially alters OHC nonlinear capacitance, the signature of electromotility - a basis of cochlear amplification. These new findings of capsaicin have ramifications for our understanding of the pharmacological properties of OHC IK, IK,n and electromotility and for interpretation of capsaicin pharmacological actions.
AB - Capsaicin, the classic activator of TRPV-1 channels in primary sensory neurons, evokes nociception. Interestingly, auditory reception is also modulated by this chemical, possibly by direct actions on outer hair cells (OHCs). Surprisingly, we find two novel actions of capsaicin unrelated to TRPV-1 channels, which likely contribute to its auditory effects in vivo. First, capsaicin is a potent blocker of OHC K conductances (IK and IK,n). Second, capsaicin substantially alters OHC nonlinear capacitance, the signature of electromotility - a basis of cochlear amplification. These new findings of capsaicin have ramifications for our understanding of the pharmacological properties of OHC IK, IK,n and electromotility and for interpretation of capsaicin pharmacological actions.
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U2 - 10.1016/j.heares.2010.10.010
DO - 10.1016/j.heares.2010.10.010
M3 - Article
C2 - 21044673
AN - SCOPUS:79751530452
SN - 0378-5955
VL - 272
SP - 117
EP - 124
JO - Hearing Research
JF - Hearing Research
IS - 1-2
ER -