TY - JOUR
T1 - Effect of Des-Tyrosine-γ-Endorphin in Tardive Dyskinesia
AU - Casey, Daniel E.
AU - Korsgaard, Søren
AU - Gerlach, Jes
AU - Jørgensen, Aage
AU - Simmelsgaard, Hans
PY - 1981/2
Y1 - 1981/2
N2 - The endorphin neuropeptides may have neuroleptic-like effects on dopamine function and may be antischizophrenic. Ten chronic psychotic patients with neuroleptic-induced tardive dyskinesia and parkinsonism received placebo and des-tyrosine-γ-endorphin (DTγE). Drug effects on movement disorders and eye-blinking rates were assessed by blind evaluations of randomly sequenced videotapes made during standardized examinations before and 30, 60, and 120 minutes after each injection and at 24 hours postinjection on days of consecutive treatment. Changes in schizophrenic symptoms were evaluated openly with the schizophrenia subscale of the Comprehensive Psychiatric Rating Scale. There were no significant effects of DTγE on any parameter and no side effects. This suggests that DTγE, within the tested dose range, does not influence the pathophysiology of neuroleptic-induced dyskinesias or chronic schizophrenia or have neuroleptic properties. However, DTγE is well tolerated and should be tested with higher doses during prolonged treatment.
AB - The endorphin neuropeptides may have neuroleptic-like effects on dopamine function and may be antischizophrenic. Ten chronic psychotic patients with neuroleptic-induced tardive dyskinesia and parkinsonism received placebo and des-tyrosine-γ-endorphin (DTγE). Drug effects on movement disorders and eye-blinking rates were assessed by blind evaluations of randomly sequenced videotapes made during standardized examinations before and 30, 60, and 120 minutes after each injection and at 24 hours postinjection on days of consecutive treatment. Changes in schizophrenic symptoms were evaluated openly with the schizophrenia subscale of the Comprehensive Psychiatric Rating Scale. There were no significant effects of DTγE on any parameter and no side effects. This suggests that DTγE, within the tested dose range, does not influence the pathophysiology of neuroleptic-induced dyskinesias or chronic schizophrenia or have neuroleptic properties. However, DTγE is well tolerated and should be tested with higher doses during prolonged treatment.
UR - http://www.scopus.com/inward/record.url?scp=0019523742&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0019523742&partnerID=8YFLogxK
U2 - 10.1001/archpsyc.1981.01780270044005
DO - 10.1001/archpsyc.1981.01780270044005
M3 - Article
C2 - 7011248
AN - SCOPUS:0019523742
SN - 0003-990X
VL - 38
SP - 158
EP - 160
JO - Archives of General Psychiatry
JF - Archives of General Psychiatry
IS - 2
ER -