Effect of spironolactone on sex hormones in man

B. Stripp, A. A. Taylor, F. C. Bartter, J. R. Gillette, D. L. Loriaux, R. Easley, R. H. Menard

Research output: Contribution to journalArticlepeer-review

81 Scopus citations


Administration of spironolactone at a dosage of 400 mg/day to healthy male volunteers for 5 days resulted in a significant rise in plasma progesterone and 17α-hydroxyprogesterone which persisted throughout the study. A transient increase in plasma FSH and LH concentration was observed after the second but not the third or fifth days of drug administration. There was no change in plasma concentration of testosterone, 17β-estradiol, or prolactin. These findings are consistent with a previously-reported spironolactone-induced destruction of the microsomal enzyme cytochrome P-450, an enzyme necessary for 17-hydroxylase and desmolase activity. The results do not explain the decrease of libido, the impotence, and the gynecomastia frequently associated with spironolactone therapy in males.

Original languageEnglish (US)
Pages (from-to)777-781
Number of pages5
JournalJournal of Clinical Endocrinology and Metabolism
Issue number4
StatePublished - Oct 1975
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical


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