Effect of third ventricular injections of prostaglandins (PG's) on gonadotropin release in conscious free moving male rats

S. R. Ojeda; P. G. Harms; S. M. McCann

doi:10.1016/0090-6980(74)90067-7

Effect of third ventricular injections of prostaglandins (PG's) on gonadotropin release in conscious free moving male rats

S. R. Ojeda
, P. G. Harms
, S. M. McCann

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Prostaglandin E₂ (PGE₂) (5 μg in 5 μl) injected into the third ventricle (3rd V) of intact or castrated conscious male rats markedly increased plasma LH titers 15 and 30 min after its injection. PGE₁ injected at a similar dose slightly increased plasma LH in intact but not in orchidectomized rats. A small but significant increase in plasma FSH followed 3rd V injection of both PGE₂ and PGE₁ in intact but not in castrated rats. PGF_1α and PGF_2α were completely ineffective in modifying plasma LH or FSH titers in either intact or castrated rats. These results indicate that PGE₂ and to a lesser extent PGE₁ specifically stimulate gonadotropin release in the male rat, possibly by a direct action on the central nervous system. They also support the hypothesis that PGE₂ and perhaps PGE₁ play a physiological role in neural control of pituitary gonadotropin release.

Original language	English (US)
Pages (from-to)	545-552
Number of pages	8
Journal	Prostaglandins
Volume	8
Issue number	6
DOIs	https://doi.org/10.1016/0090-6980(74)90067-7
State	Published - Dec 25 1974
Externally published	Yes

Funding

*Supported by grants from NIH (AM 10073 and HD 05151), the Ford Foundation and the Texas Population Research Institute.

Funders	Funder number
Texas Population Research Institute
Author National Institutes of Health National Institutes of Health National Institutes of Health National Institutes of Health The Bev Hartig Huntington's Disease Foundation National Institutes of Health	HD 05151, AM 10073
Ford Foundation

ASJC Scopus subject areas

Biochemistry
Endocrinology

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10.1016/0090-6980(74)90067-7

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title = "Effect of third ventricular injections of prostaglandins (PG's) on gonadotropin release in conscious free moving male rats",

abstract = "Prostaglandin E2 (PGE2) (5 μg in 5 μl) injected into the third ventricle (3rd V) of intact or castrated conscious male rats markedly increased plasma LH titers 15 and 30 min after its injection. PGE1 injected at a similar dose slightly increased plasma LH in intact but not in orchidectomized rats. A small but significant increase in plasma FSH followed 3rd V injection of both PGE2 and PGE1 in intact but not in castrated rats. PGF1α and PGF2α were completely ineffective in modifying plasma LH or FSH titers in either intact or castrated rats. These results indicate that PGE2 and to a lesser extent PGE1 specifically stimulate gonadotropin release in the male rat, possibly by a direct action on the central nervous system. They also support the hypothesis that PGE2 and perhaps PGE1 play a physiological role in neural control of pituitary gonadotropin release.",

author = "Ojeda, \{S. R.\} and Harms, \{P. G.\} and McCann, \{S. M.\}",

note = "Funding Information: *Supported by grants from NIH (AM 10073 and HD 05151), the Ford Foundation and the Texas Population Research Institute.",

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doi = "10.1016/0090-6980(74)90067-7",

language = "English (US)",

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TY - JOUR

T1 - Effect of third ventricular injections of prostaglandins (PG's) on gonadotropin release in conscious free moving male rats

AU - Ojeda, S. R.

AU - Harms, P. G.

AU - McCann, S. M.

N1 - Funding Information: *Supported by grants from NIH (AM 10073 and HD 05151), the Ford Foundation and the Texas Population Research Institute.

PY - 1974/12/25

Y1 - 1974/12/25

N2 - Prostaglandin E2 (PGE2) (5 μg in 5 μl) injected into the third ventricle (3rd V) of intact or castrated conscious male rats markedly increased plasma LH titers 15 and 30 min after its injection. PGE1 injected at a similar dose slightly increased plasma LH in intact but not in orchidectomized rats. A small but significant increase in plasma FSH followed 3rd V injection of both PGE2 and PGE1 in intact but not in castrated rats. PGF1α and PGF2α were completely ineffective in modifying plasma LH or FSH titers in either intact or castrated rats. These results indicate that PGE2 and to a lesser extent PGE1 specifically stimulate gonadotropin release in the male rat, possibly by a direct action on the central nervous system. They also support the hypothesis that PGE2 and perhaps PGE1 play a physiological role in neural control of pituitary gonadotropin release.

AB - Prostaglandin E2 (PGE2) (5 μg in 5 μl) injected into the third ventricle (3rd V) of intact or castrated conscious male rats markedly increased plasma LH titers 15 and 30 min after its injection. PGE1 injected at a similar dose slightly increased plasma LH in intact but not in orchidectomized rats. A small but significant increase in plasma FSH followed 3rd V injection of both PGE2 and PGE1 in intact but not in castrated rats. PGF1α and PGF2α were completely ineffective in modifying plasma LH or FSH titers in either intact or castrated rats. These results indicate that PGE2 and to a lesser extent PGE1 specifically stimulate gonadotropin release in the male rat, possibly by a direct action on the central nervous system. They also support the hypothesis that PGE2 and perhaps PGE1 play a physiological role in neural control of pituitary gonadotropin release.

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UR - https://www.scopus.com/pages/publications/0016330420#tab=citedBy

U2 - 10.1016/0090-6980(74)90067-7

DO - 10.1016/0090-6980(74)90067-7

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AN - SCOPUS:0016330420

SN - 0090-6980

VL - 8

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JO - Prostaglandins

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IS - 6

ER -

Effect of third ventricular injections of prostaglandins (PG's) on gonadotropin release in conscious free moving male rats

Abstract

Funding

ASJC Scopus subject areas

Access to Document

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