Effects of a selective inhibitor of the Ab1 tyrosine kinase on the growth of Bcr-Ab1 positive cells

Brian J. Druker; Shu Tamura; Elisabeth Buchdunger; Sayuri Ohno; Gerald M. Segal; Shake Fanning; Jürg Zimmermann; Nicholas B. Lydon

doi:10.1038/nm0596-561

Effects of a selective inhibitor of the Ab1 tyrosine kinase on the growth of Bcr-Ab1 positive cells

Brian J. Druker, Shu Tamura, Elisabeth Buchdunger, Sayuri Ohno, Gerald M. Segal, Shake Fanning, Jürg Zimmermann, Nicholas B. Lydon

Knight Cancer Institute

Research output: Contribution to journal › Article › peer-review

3218 Scopus citations

Abstract

The bcr-abl oncogene, present in 95% of patients with chronic myelogenous leukemia (CML), has been implicated as the cause of this disease. A compound, designed to inhibit the Abl protein tyrosine kinase, was evaluated for its effects on cells containing the Bcr-Abl fusion protein. Cellular proliferation and tumor formation by Bcr-Abl-expressing cells were specifically inhibited by this compound. In colony-forming assays of peripheral blood or bone marrow from patients with CML, there was a 92-98% decrease in the number of bcr-abl colonies formed but no inhibition of normal colony formation. This compound may be useful in the treatment of bcr-abl-positive leukemias.

Original language	English (US)
Pages (from-to)	561-566
Number of pages	6
Journal	Nature medicine
Volume	2
Issue number	5
DOIs	https://doi.org/10.1038/nm0596-561
State	Published - 1996

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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abstract = "The bcr-abl oncogene, present in 95% of patients with chronic myelogenous leukemia (CML), has been implicated as the cause of this disease. A compound, designed to inhibit the Abl protein tyrosine kinase, was evaluated for its effects on cells containing the Bcr-Abl fusion protein. Cellular proliferation and tumor formation by Bcr-Abl-expressing cells were specifically inhibited by this compound. In colony-forming assays of peripheral blood or bone marrow from patients with CML, there was a 92-98% decrease in the number of bcr-abl colonies formed but no inhibition of normal colony formation. This compound may be useful in the treatment of bcr-abl-positive leukemias.",

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AU - Segal, Gerald M.

AU - Fanning, Shake

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AU - Lydon, Nicholas B.

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Effects of a selective inhibitor of the Ab1 tyrosine kinase on the growth of Bcr-Ab1 positive cells

Abstract

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