Abstract
The effects of diethylpropion were determined and compared with those of d-amphetamine in 9 subjects using a crossover design. Diethylpropion produced effects qualitatively similar to those of d-amphetamine, but significantly less potent. Orally diethylpropion was 1 6 to 1 11 as potent as d-amphetamine while subcutaneously diethylpropion was 1 10 to 1 20 as potent as d-amphetamine. A striking difference between diethylpropion and d-amphetamine was the relatively greater oral efficacy of diethylpropion. Diethylpropion was twice as potent orally as subcutaneously while oral and subcutaneous d-amphetamine were equipotent.
Original language | English (US) |
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Pages (from-to) | 645-652 |
Number of pages | 8 |
Journal | Clinical pharmacology and therapeutics |
Volume | 16 |
Issue number | 4 |
DOIs | |
State | Published - Oct 1974 |
Externally published | Yes |
ASJC Scopus subject areas
- Pharmacology
- Pharmacology (medical)