Vliv specifické inhibice cyklooxygenázy 2 na ledvinové funkce u starších pacientů s poruchou ledvinové funkce

M. Horáčková; O. Schück; R. Komers; V. Teplan; J. Charvát; M. Kvapil

Vliv specifické inhibice cyklooxygenázy 2 na ledvinové funkce u starších pacientů s poruchou ledvinové funkce

Translated title of the contribution: Effects of specific cycloxygenase- 2 inhibition on the renal functions of elderly patients with renal function impairment

M. Horáčková, O. Schück, R. Komers, V. Teplan, J. Charvát, M. Kvapil

Research output: Contribution to journal › Article › peer-review

Abstract

Background. Elderly patients suffering from nociceptive pain of locomotive organs and concomitantly from renal impairment represent a target population for painkilling drugs. That is why they are predisposed to nephrotoxic effects non-steroidal anti-inflammatory drugs. The aim of our study was to evaluate cycloxygenase-2 (COX-2) inhibition effect on renal function in elderly with moderate impairment of renal function. Methods and Results. Based on 24-h urine collection we assessed creatinine clearance (C_Cr), fractional excretion of sodium (FE_Na), potassium (FE_K), chloride (FE_Cl), osmotic active solutes (FE_OSM) and 24h urinary excretion of prostaglandin PGE₂ and PGF_2α. Under conditions of sub-maximal water load fractional excretion of electrolytes, inulin clearance (C_in), serum cystatin C (S_cyst) were assessed. In addition basal and stimulated plasma renin activity (PRA) and plasma aldosteron (P_aldo) were examined. Using comparison of parameters before and at the end of 7-days rofecoxib treatment we found out C_in 0,82±0,34 vs 0,74±0,18 ml/s/1,73 m², FE_Na 1,0±0,3 vs 1,2±0,4 (p=0,02), FE_OSM 2,9±0,7 vs 3,7±1,2% (p=0,03), U_PGE2α V 663±528 vs 414±195 (p=0,059), U_PGF2 V (559±625) vs 205±174 ηg/24h (p=0,02), stimulated PRA 0,94±0,73 vs 0,4±0,27 ±pg/1/h (p=0,019), P_aldo 104,56±50,15 vs 56,94±27,08 ηg/l/h (p=0,008). Conclusions. Short-term COX-2 inhibition in patients with moderate renal impairment was associated with significant decrease of tubular transport of sodium, without changing GFR and water excretion.

Translated title of the contribution	Effects of specific cycloxygenase- 2 inhibition on the renal functions of elderly patients with renal function impairment
Original language	Slovak
Pages (from-to)	777-781
Number of pages	5
Journal	Casopis Lekaru Ceskych
Volume	145
Issue number	10
State	Published - 2006
Externally published	Yes

Keywords

Coclooxygenase-2 inhibition
Renal function
Renal insufficiency

ASJC Scopus subject areas

Medicine(all)

Cite this

@article{49ac0d3739894728896f922e6643ebd0,

title = "Vliv specifick{\'e} inhibice cyklooxygen{\'a}zy 2 na ledvinov{\'e} funkce u star{\v s}{\'i}ch pacientů s poruchou ledvinov{\'e} funkce",

abstract = "Background. Elderly patients suffering from nociceptive pain of locomotive organs and concomitantly from renal impairment represent a target population for painkilling drugs. That is why they are predisposed to nephrotoxic effects non-steroidal anti-inflammatory drugs. The aim of our study was to evaluate cycloxygenase-2 (COX-2) inhibition effect on renal function in elderly with moderate impairment of renal function. Methods and Results. Based on 24-h urine collection we assessed creatinine clearance (CCr), fractional excretion of sodium (FENa), potassium (FEK), chloride (FECl), osmotic active solutes (FEOSM) and 24h urinary excretion of prostaglandin PGE2 and PGF2α. Under conditions of sub-maximal water load fractional excretion of electrolytes, inulin clearance (Cin), serum cystatin C (Scyst) were assessed. In addition basal and stimulated plasma renin activity (PRA) and plasma aldosteron (Paldo) were examined. Using comparison of parameters before and at the end of 7-days rofecoxib treatment we found out Cin 0,82±0,34 vs 0,74±0,18 ml/s/1,73 m2, FENa 1,0±0,3 vs 1,2±0,4 (p=0,02), FEOSM 2,9±0,7 vs 3,7±1,2% (p=0,03), UPGE2α V 663±528 vs 414±195 (p=0,059), UPGF2 V (559±625) vs 205±174 ηg/24h (p=0,02), stimulated PRA 0,94±0,73 vs 0,4±0,27 ±pg/1/h (p=0,019), Paldo 104,56±50,15 vs 56,94±27,08 ηg/l/h (p=0,008). Conclusions. Short-term COX-2 inhibition in patients with moderate renal impairment was associated with significant decrease of tubular transport of sodium, without changing GFR and water excretion.",

keywords = "Coclooxygenase-2 inhibition, Renal function, Renal insufficiency",

author = "M. Hor{\'a}{\v c}kov{\'a} and O. Sch{\"u}ck and R. Komers and V. Teplan and J. Charv{\'a}t and M. Kvapil",

year = "2006",

language = "Slovak",

volume = "145",

pages = "777--781",

journal = "Casopis Lekaru Ceskych",

issn = "0008-7335",

publisher = "Czech Medical Association J.E. Purkyne",

number = "10",

}

TY - JOUR

T1 - Vliv specifické inhibice cyklooxygenázy 2 na ledvinové funkce u starších pacientů s poruchou ledvinové funkce

AU - Horáčková, M.

AU - Schück, O.

AU - Komers, R.

AU - Teplan, V.

AU - Charvát, J.

AU - Kvapil, M.

PY - 2006

Y1 - 2006

N2 - Background. Elderly patients suffering from nociceptive pain of locomotive organs and concomitantly from renal impairment represent a target population for painkilling drugs. That is why they are predisposed to nephrotoxic effects non-steroidal anti-inflammatory drugs. The aim of our study was to evaluate cycloxygenase-2 (COX-2) inhibition effect on renal function in elderly with moderate impairment of renal function. Methods and Results. Based on 24-h urine collection we assessed creatinine clearance (CCr), fractional excretion of sodium (FENa), potassium (FEK), chloride (FECl), osmotic active solutes (FEOSM) and 24h urinary excretion of prostaglandin PGE2 and PGF2α. Under conditions of sub-maximal water load fractional excretion of electrolytes, inulin clearance (Cin), serum cystatin C (Scyst) were assessed. In addition basal and stimulated plasma renin activity (PRA) and plasma aldosteron (Paldo) were examined. Using comparison of parameters before and at the end of 7-days rofecoxib treatment we found out Cin 0,82±0,34 vs 0,74±0,18 ml/s/1,73 m2, FENa 1,0±0,3 vs 1,2±0,4 (p=0,02), FEOSM 2,9±0,7 vs 3,7±1,2% (p=0,03), UPGE2α V 663±528 vs 414±195 (p=0,059), UPGF2 V (559±625) vs 205±174 ηg/24h (p=0,02), stimulated PRA 0,94±0,73 vs 0,4±0,27 ±pg/1/h (p=0,019), Paldo 104,56±50,15 vs 56,94±27,08 ηg/l/h (p=0,008). Conclusions. Short-term COX-2 inhibition in patients with moderate renal impairment was associated with significant decrease of tubular transport of sodium, without changing GFR and water excretion.

AB - Background. Elderly patients suffering from nociceptive pain of locomotive organs and concomitantly from renal impairment represent a target population for painkilling drugs. That is why they are predisposed to nephrotoxic effects non-steroidal anti-inflammatory drugs. The aim of our study was to evaluate cycloxygenase-2 (COX-2) inhibition effect on renal function in elderly with moderate impairment of renal function. Methods and Results. Based on 24-h urine collection we assessed creatinine clearance (CCr), fractional excretion of sodium (FENa), potassium (FEK), chloride (FECl), osmotic active solutes (FEOSM) and 24h urinary excretion of prostaglandin PGE2 and PGF2α. Under conditions of sub-maximal water load fractional excretion of electrolytes, inulin clearance (Cin), serum cystatin C (Scyst) were assessed. In addition basal and stimulated plasma renin activity (PRA) and plasma aldosteron (Paldo) were examined. Using comparison of parameters before and at the end of 7-days rofecoxib treatment we found out Cin 0,82±0,34 vs 0,74±0,18 ml/s/1,73 m2, FENa 1,0±0,3 vs 1,2±0,4 (p=0,02), FEOSM 2,9±0,7 vs 3,7±1,2% (p=0,03), UPGE2α V 663±528 vs 414±195 (p=0,059), UPGF2 V (559±625) vs 205±174 ηg/24h (p=0,02), stimulated PRA 0,94±0,73 vs 0,4±0,27 ±pg/1/h (p=0,019), Paldo 104,56±50,15 vs 56,94±27,08 ηg/l/h (p=0,008). Conclusions. Short-term COX-2 inhibition in patients with moderate renal impairment was associated with significant decrease of tubular transport of sodium, without changing GFR and water excretion.

KW - Coclooxygenase-2 inhibition

KW - Renal function

KW - Renal insufficiency

UR - http://www.scopus.com/inward/record.url?scp=33750399103&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33750399103&partnerID=8YFLogxK

M3 - Article

C2 - 17121069

AN - SCOPUS:33750399103

SN - 0008-7335

VL - 145

SP - 777

EP - 781

JO - Casopis Lekaru Ceskych

JF - Casopis Lekaru Ceskych

IS - 10

ER -

Vliv specifické inhibice cyklooxygenázy 2 na ledvinové funkce u starších pacientů s poruchou ledvinové funkce

Abstract

Keywords

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this