Abstract
All muscle relaxants inhibit histamine N-methyltransferase in vitro, but vecuronium, a steroid-derived muscle relaxant, is the most potent inhibitor. It has been suggested that administration of vecuronium prior to giving a drug that releases histamine may exaggerate the hemodynamic or vascular effects. Volunteers were injected intradermally with 5×10-4M concentrations of histamine, and the combination of vecuronium and histamine, to evaluate the in vivo significance. Vecuronium did not alter the measured wheal and flare responses to injected histamine at 5, 15, 30, 40, 50 and 60 mins. There is no evidence that inhibition of histamine N-methyltransferase in vivo will alter the vascular effects of histamine.
Original language | English (US) |
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Pages (from-to) | C211-C212 |
Journal | Agents and Actions |
Volume | 36 |
Issue number | 2 Supplement |
DOIs | |
State | Published - Jun 1992 |
Externally published | Yes |
ASJC Scopus subject areas
- Toxicology
- Pharmacology (medical)