Electrocoating carbon fiber microelectrodes with Nafion improves selectivity for electroactive neurotransmitters

M. P. Brazell; R. J. Kasser; K. J. Renner; J. Feng; B. Moghaddam; R. N. Adams

doi:10.1016/0165-0270(87)90011-2

Electrocoating carbon fiber microelectrodes with Nafion improves selectivity for electroactive neurotransmitters

M. P. Brazell
, R. J. Kasser
, K. J. Renner
, J. Feng
, B. Moghaddam
, R. N. Adams

Research output: Contribution to journal › Article › peer-review

138 Scopus citations

Abstract

A method which improves carbon fiber microelectrode selectivity for cationic amines by electrocoating the fiber with a thin film of the ionic polymer, Nafion, is described. The selectivity and response speed of these electrodes for the detection of electroactive cationic and anionic species found in brain extracellular fluid was evaluated using differential pulse voltammetry and chronoamperometry and compared to uncoated fibers. Carbon fiber microelectrodes electrocoated with Nafion are highly sensitive to cationic amines such as dopamine and serotonin and have minimal sensitivity to anions such as ascorbic acid and uric acid at physiological concentrations.

Original language	English (US)
Pages (from-to)	167-172
Number of pages	6
Journal	Journal of Neuroscience Methods
Volume	22
Issue number	2
DOIs	https://doi.org/10.1016/0165-0270(87)90011-2
State	Published - Dec 1987
Externally published	Yes

Funding

This work wa~ supported by a Traveling Fellowship Grant from the United Kingdom Medical Research Council (M.P.B.), NIH Grant NS-08740 (K.J.R.), Javits Neuroscience Investigator Award (R.N.A.), and the University of Kansas Center for Bioanalytical Research High Technology Division (R.J.K.). We are grateful to AVCO Specialty Materials Division, Lowell, MA for donation of carbon fibers and to Charles Rennet for suggesting the electrocoating procedure.

Funders	Funder number
Medical Research Council of the United Kingdom
University of Kansas Center for Bioanalytical Research High Technology Division
Author National Institutes of Health National Institutes of Health National Institutes of Health National Institutes of Health The Bev Hartig Huntington's Disease Foundation National Institutes of Health
National Institute of Neurological Disorders and Stroke	R01NS008740

Keywords

Carbon fiber microelectrode
Chronoamperometry
Differential pulse voltammetry
Electrocoating
Nafion
Selectivity

ASJC Scopus subject areas

General Neuroscience

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10.1016/0165-0270(87)90011-2

Cite this

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title = "Electrocoating carbon fiber microelectrodes with Nafion improves selectivity for electroactive neurotransmitters",

abstract = "A method which improves carbon fiber microelectrode selectivity for cationic amines by electrocoating the fiber with a thin film of the ionic polymer, Nafion, is described. The selectivity and response speed of these electrodes for the detection of electroactive cationic and anionic species found in brain extracellular fluid was evaluated using differential pulse voltammetry and chronoamperometry and compared to uncoated fibers. Carbon fiber microelectrodes electrocoated with Nafion are highly sensitive to cationic amines such as dopamine and serotonin and have minimal sensitivity to anions such as ascorbic acid and uric acid at physiological concentrations.",

keywords = "Carbon fiber microelectrode, Chronoamperometry, Differential pulse voltammetry, Electrocoating, Nafion, Selectivity",

author = "Brazell, \{M. P.\} and Kasser, \{R. J.\} and Renner, \{K. J.\} and J. Feng and B. Moghaddam and Adams, \{R. N.\}",

note = "Funding Information: This work wa\textasciitilde{} supported by a Traveling Fellowship Grant from the United Kingdom Medical Research Council (M.P.B.), NIH Grant NS-08740 (K.J.R.), Javits Neuroscience Investigator Award (R.N.A.), and the University of Kansas Center for Bioanalytical Research High Technology Division (R.J.K.). We are grateful to AVCO Specialty Materials Division, Lowell, MA for donation of carbon fibers and to Charles Rennet for suggesting the electrocoating procedure.",

year = "1987",

month = dec,

doi = "10.1016/0165-0270(87)90011-2",

language = "English (US)",

volume = "22",

pages = "167--172",

journal = "Journal of Neuroscience Methods",

issn = "0165-0270",

publisher = "Elsevier B.V.",

number = "2",

}

TY - JOUR

T1 - Electrocoating carbon fiber microelectrodes with Nafion improves selectivity for electroactive neurotransmitters

AU - Brazell, M. P.

AU - Kasser, R. J.

AU - Renner, K. J.

AU - Feng, J.

AU - Moghaddam, B.

AU - Adams, R. N.

N1 - Funding Information: This work wa~ supported by a Traveling Fellowship Grant from the United Kingdom Medical Research Council (M.P.B.), NIH Grant NS-08740 (K.J.R.), Javits Neuroscience Investigator Award (R.N.A.), and the University of Kansas Center for Bioanalytical Research High Technology Division (R.J.K.). We are grateful to AVCO Specialty Materials Division, Lowell, MA for donation of carbon fibers and to Charles Rennet for suggesting the electrocoating procedure.

PY - 1987/12

Y1 - 1987/12

N2 - A method which improves carbon fiber microelectrode selectivity for cationic amines by electrocoating the fiber with a thin film of the ionic polymer, Nafion, is described. The selectivity and response speed of these electrodes for the detection of electroactive cationic and anionic species found in brain extracellular fluid was evaluated using differential pulse voltammetry and chronoamperometry and compared to uncoated fibers. Carbon fiber microelectrodes electrocoated with Nafion are highly sensitive to cationic amines such as dopamine and serotonin and have minimal sensitivity to anions such as ascorbic acid and uric acid at physiological concentrations.

AB - A method which improves carbon fiber microelectrode selectivity for cationic amines by electrocoating the fiber with a thin film of the ionic polymer, Nafion, is described. The selectivity and response speed of these electrodes for the detection of electroactive cationic and anionic species found in brain extracellular fluid was evaluated using differential pulse voltammetry and chronoamperometry and compared to uncoated fibers. Carbon fiber microelectrodes electrocoated with Nafion are highly sensitive to cationic amines such as dopamine and serotonin and have minimal sensitivity to anions such as ascorbic acid and uric acid at physiological concentrations.

KW - Carbon fiber microelectrode

KW - Chronoamperometry

KW - Differential pulse voltammetry

KW - Electrocoating

KW - Nafion

KW - Selectivity

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U2 - 10.1016/0165-0270(87)90011-2

DO - 10.1016/0165-0270(87)90011-2

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SN - 0165-0270

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JO - Journal of Neuroscience Methods

JF - Journal of Neuroscience Methods

IS - 2

ER -

Electrocoating carbon fiber microelectrodes with Nafion improves selectivity for electroactive neurotransmitters

Abstract

Funding

Keywords

ASJC Scopus subject areas

Access to Document

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