Electrocorticographic events from long-term ambulatory brain recordings can potentially supplement seizure diaries

Mark Quigg, Tara L. Skarpaas, David C. Spencer, Nathan B. Fountain, Beata Jarosiewicz, Martha J. Morrell

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Purpose: To determine the feasibility of using epileptiform events detected by continuous electrocorticographic monitoring via a brain-responsive neurostimulation system to supplement patient-maintained seizure diaries. Methods: Data were retrospectively analyzed from a randomized controlled trial of brain-responsive neurostimulation (RNS® System) for adjunctive treatment of medically intractable focal onset seizures in 191 subjects. The long-term (≥3 months) correspondence between daily counts of diary-reported seizures and device-recorded “long epileptiform events” (LEs), a proxy for electrographic seizures (ESs), was assessed using cross-correlation and logistic generalized estimating equation models. Results: Diary-reported seizures and LEs significantly co-varied across days in 124 patients whose detection settings were held constant, with a significantly higher correlation in 54 patients (44 %) whose LEs were usually ESs (high concordance patients). There were more days in which LEs were detected than days in which patients reported a seizure (positive predictive value (PPV): 34 %). On days when there were no LEs, there were typically no diary-reported seizures (negative predictive value (NPV): 90 %). In patients with a high concordance between LEs and ESs, the PPV and NPV were both slightly higher, 43 % (35–52 %) and 93 % (95 % CI: 86–97 %) respectively. Conclusion: Although LEs can substantially outnumber diary reported seizures, the high across-day correlation and strong NPV between LEs and diary seizures suggests that LEs recorded by the RNS® System could potentially supplement seizure diaries by providing an objective biomarker for relative seizure burden.

Original languageEnglish (US)
Article number106302
JournalEpilepsy Research
Volume161
DOIs
StatePublished - Mar 2020

Keywords

  • Clinical trial
  • Electrocorticography
  • Focal seizure
  • Neurostimulation

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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