@article{3af9e125666f40edbb84116d7b1a411a,
title = "Electron Beam Irradiated Corneal Versus Gamma-Irradiated Scleral Patch Graft Erosion Rates in Glaucoma Drainage Device Surgery",
abstract = "Introduction: Patch graft erosion and implant exposure is a known complication of glaucoma drainage device (GDD) surgery. Recently, electron beam (e-beam) irradiated corneal tissue has become available; however, limited data exist on the rates of erosion for e-beam irradiated corneal grafts compared to traditional scleral grafts after GDD surgery. Methods: This retrospective study examines the records of 253 eyes from 225 adult subjects who underwent GDD surgery with either e-beam irradiated corneal or scleral grafts at the Casey Eye Institute by five surgeons between April 22, 2014 and October 11, 2017. Surgical procedures and the occurrence of graft erosion were determined using billing codes and verified by manual review of electronic health records. Results: The average age at the time of surgery was 61.3 ± 17.5 years (n = 200) and 60.8 ± 16.8 years (n = 53) for the e-beam irradiated cornea and sclera groups, respectively. The average follow-up time post-surgery was 416 ± 345 days and 495 ± 343 days for the e-beam irradiated cornea and sclera groups, respectively. There were no statistically significant differences in sex, age, follow-up time, and glaucoma diagnosis between the groups; however, the e-beam irradiated cornea group was statistically more likely to have an Ahmed implant as compared to the sclera group. No erosion events were noted in either group. Conclusion: e-Beam irradiated corneal grafts were used 3.8 times more frequently relative to scleral grafts, yet there were no cases of graft erosion in either group during the follow-up period.",
keywords = "Corneal patch graft, Glaucoma drainage device (GDD), Graft erosion, Scleral patch graft, Tube exposure",
author = "Passo, {Ross M.} and Hoskins, {Zachary B.} and Tran, {Khoa D.} and Corrina Patzer and Beth Edmunds and Morrison, {John C.} and Mansi Parikh and Hana Takusagawa and Shandiz Tehrani",
note = "Funding Information: We thank the participants of the study. This study was funded by the National Eye Institute (Bethesda, MD; P30EY010572) and an unrestricted grant from Research to Prevent Blindness (New York, NY). All authors had full access to all of the data in this study and take complete responsibility for the integrity of the data and accuracy of the data analysis. The article processing charges were funded by the authors. All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this article, take responsibility for the integrity of the work as a whole, and have given their approval for this version to be published. Khoa D. Tran is an employee of Lions VisionGift (Portland, OR). Corrina Patzer is an employee of Lions VisionGift. Shandiz Tehrani is a volunteer/unpaid member of the Lions VisionGift Medical Advising Committee. Ross M. Passo, Zachary B. Hoskins, Beth Edmunds, John C. Morrison, Mansi Parikh, and Hana L. Takusagawa have nothing to disclose. All procedures were in accordance with the Institutional Review Board of Oregon Health and Science University (FWA00000161; IRB00000471) and with the Helsinki Declaration of 1964, as revised in 2013, concerning human and animal rights. Springer{\textquoteright}s policy concerning informed consent has been followed. Informed consent was obtained from all human subjects. The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Funding Information: This study was funded by the National Eye Institute (Bethesda, MD; P30EY010572) and an unrestricted grant from Research to Prevent Blindness (New York, NY). All authors had full access to all of the data in this study and take complete responsibility for the integrity of the data and accuracy of the data analysis. The article processing charges were funded by the authors. Publisher Copyright: {\textcopyright} 2019, The Author(s).",
year = "2019",
month = sep,
day = "1",
doi = "10.1007/s40123-019-0190-x",
language = "English (US)",
volume = "8",
pages = "421--426",
journal = "Ophthalmology and Therapy",
issn = "2193-8245",
publisher = "Springer London",
number = "3",
}