Electron microscopy and HLA expression of a new cell line of retinoblastoma

G. A. Fournier, D. N. Sang, D. M. Albert, J. L. Craft

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


A new continuous retinoblastoma cell line (Rb 355-7) derived from a nonfamilial unilaterally-affected child was studied morphologically and with regard to HLA expression. The tumor was compared with two older and widely studied cell lines, the Y-79 and WERI-Rb1 strains. The Rb 355-7 line grew in tissue culture in clusters and chains. Its doubling time was calculated to be 4.4 days. In contrast to the Y-79 and WERI-Rb1 cell lines, the Rb355-7 showed a paucity of HLA expression.

Original languageEnglish (US)
Pages (from-to)690-699
Number of pages10
JournalInvestigative Ophthalmology and Visual Science
Issue number4
StatePublished - 1987
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


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