Endemic pemphigus vulgaris

Rosicler Rocha-Alvarez, Alex G. Ortega-Loayza, Horacio Friedman, Iphis Campbell, Valeria Aoki, Evandro A. Rivitti, David Dasher, Ning Li, Luis A. Diaz

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


Background: Investigators from Brasilia, Brazil, observed several patients with a mucocutaneous disease that resembles pemphigus vulgaris clinically and histologically but with epidemiological features of fogo selvagem. Our objective was to characterize antidesmoglein 3 and antidesmoglein 1 autoantibody profiles in these unique patients who reside in Goiânia and Brasilia, Brazil, known endemic regions of fogo selvagem. Observations: We performed serological evaluation of 8 patients with a mucocutaneous disease clinically and histologically consistent with pemphigus vulgaris, as well as 27 healthy relatives of patients with fogo selvagem who reside in these endemic areas. Serum samples from all 8 patients bound desmoglein 3 by cold immunoprecipitation and from 6 patients by enzyme-linked immunosorbent assay, while serum samples from 4 patients bound desmoglein 1 by cold immunoprecipitation and by enzyme-linked immunosorbent assay. Antidesmoglein 3 autoantibodies were detected in 4 of 27 healthy donors by cold immunoprecipitation and by enzyme-linked immunosorbent assay, whereas antidesmoglein 1 autoantibodies were detected in 6 individuals by cold immunoprecipitation and in 3 individuals by enzyme-linked immunosorbent assay. Conclusion: These findings provide serological evidence of a new endemic variant of pemphigus vulgaris.

Original languageEnglish (US)
Pages (from-to)895-899
Number of pages5
JournalArchives of Dermatology
Issue number7
StatePublished - Jul 2007
Externally publishedYes

ASJC Scopus subject areas

  • Dermatology


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