Endovascular Therapy for Basilar Artery Occlusion: Among the First to Conceptualize, Last to Prove

Volker Puetz, Helmi L. Lutsep, Thanh N. Nguyen

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations


In 1981, the dismal outcomes of patients with basilar artery occlusion (BAO) inspired the first reports of intra-arterial thrombolytic treatment in BAO. These reports were among the first to conceptualize that opening an artery could help patients with large vessel occlusion stroke. Whereas multiple anterior circulation LVO trials demonstrated the efficacy of endovascular therapy starting in 2014, proof of benefit for BAO was lacking until 2022. In this commentary, we reflect on how the BASICS (Basilar Artery International Cooperation Study) and BEST (Basilar Artery Occlusion: Endovascular Interventions vs Standard Medical Treatment) trials lay the foundations for clinical trials in BAO, subsequently leading to the positive results of the ATTENTION (Endovascular Treatment for Acute Basilar-Artery Occlusion) and BAOCHE (Basilar Artery Occlusion Chinese Endovascular) trials.

Original languageEnglish (US)
Pages (from-to)905-908
Number of pages4
Issue number3
StatePublished - Mar 1 2023


  • basilar artery
  • endovascular procedures
  • ischemic stroke
  • randomized controlled trial

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing


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