TY - JOUR
T1 - Engaging neuroscience to advance translational research in brain barrier biology
AU - Neuwelt, Edward A.
AU - Bauer, Björn
AU - Fahlke, Christoph
AU - Fricker, Gert
AU - Iadecola, Constantino
AU - Janigro, Damir
AU - Leybaert, Luc
AU - Molnár, Zoltán
AU - O'Donnell, Martha E.
AU - Povlishock, John T.
AU - Saunders, Norman R.
AU - Sharp, Frank
AU - Stanimirovic, Danica
AU - Watts, Ryan J.
AU - Drewes, Lester R.
N1 - Funding Information:
The meeting on which this report was based was partially funded by an R13 grant from the US National Institutes of Health (Grant 5 R13 CA086959-10). We would like to thank all of the people who attended the Engaging Neuroscience to Advance Brain Barriers Translational Research meeting (March 19–21, 2009), Gleneden Beach, Oregon, USA. Special thanks to Lester Drewes, Martha O’Donnell, Leslie Muldoon and Aliana Kim who were instrumental in the development of this report.
PY - 2011/3
Y1 - 2011/3
N2 - The delivery of many potentially therapeutic and diagnostic compounds to specific areas of the brain is restricted by brain barriers, of which the most well known are the blood-brain barrier (BBB) and the blood-cerebrospinal fluid (CSF) barrier. Recent studies have shown numerous additional roles of these barriers, including an involvement in neurodevelopment, in the control of cerebral blood flow, and - when barrier integrity is impaired - in the pathology of many common CNS disorders such as Alzheimer's disease, Parkinson's disease and stroke.
AB - The delivery of many potentially therapeutic and diagnostic compounds to specific areas of the brain is restricted by brain barriers, of which the most well known are the blood-brain barrier (BBB) and the blood-cerebrospinal fluid (CSF) barrier. Recent studies have shown numerous additional roles of these barriers, including an involvement in neurodevelopment, in the control of cerebral blood flow, and - when barrier integrity is impaired - in the pathology of many common CNS disorders such as Alzheimer's disease, Parkinson's disease and stroke.
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U2 - 10.1038/nrn2995
DO - 10.1038/nrn2995
M3 - Review article
C2 - 21331083
AN - SCOPUS:79951922143
SN - 1471-003X
VL - 12
SP - 169
EP - 182
JO - Nature Reviews Neuroscience
JF - Nature Reviews Neuroscience
IS - 3
ER -