Abstract
Although skeletal muscle is highly regenerative following injury or disease, endogenous self-regeneration is severely impaired in conditions of volume traumatic muscle loss. Consequently, tissue engineering approaches are a promising means to regenerate skeletal muscle. Biological scaffolds serve as not only structural support for the promotion of cellular ingrowth but also impart potent modulatory signaling cues that may be beneficial for tissue regeneration. In this work, the progress of tissue engineering approaches for skeletal muscle engineering and regeneration is overviewed, with a focus on the techniques to create biomimetic engineered tissue using extracellular cues. These factors include mechanical and electrical stimulation, geometric patterning, and delivery of growth factors or other bioactive molecules. The progress of evaluating the therapeutic efficacy of these approaches in preclinical models of muscle injury is further discussed.
Original language | English (US) |
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Article number | 1801168 |
Journal | Advanced Healthcare Materials |
Volume | 8 |
Issue number | 5 |
DOIs | |
State | Published - Mar 7 2019 |
Externally published | Yes |
Keywords
- biomaterials
- skeletal muscle regeneration
- spatial patterning
- volumetric muscle loss
ASJC Scopus subject areas
- Biomaterials
- Biomedical Engineering
- Pharmaceutical Science