Enkephalinergic modulation of non-cholinergic transmission in mammalian prevertebral ganglia

Z. G. Jiang; M. A. Simmons; N. J. Dun

doi:10.1016/0006-8993(82)90211-6

Enkephalinergic modulation of non-cholinergic transmission in mammalian prevertebral ganglia

Z. G. Jiang, M. A. Simmons, N. J. Dun

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

The non-cholinergic excitatory potential elicited in neurons of the isolated inferior mesentric ganglia was depressed by bath application of Met- and Leu-enkephalin and enhanced by naloxone or naltrexone. The membrane depolarization induced by exogenously applied putative transmitter substance P was not appreciably affected by either enkephalin (Enk) or opiate antagonists. Our results indicate that the non-cholinergic excitatory transmission which may be mediated by substance P in prevertebral ganglia is modulated presynaptically by endogenously released Enk in a manner that may resemble the interaction between these two peptides in the spinal cord.

Original language	English (US)
Pages (from-to)	185-191
Number of pages	7
Journal	Brain research
Volume	235
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(82)90211-6
State	Published - Mar 4 1982
Externally published	Yes

Keywords

enkephalin
presynaptic modulation
substance P

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

Access to Document

10.1016/0006-8993(82)90211-6

Cite this

@article{0073bbcfca3a4484801612348fd621c7,

title = "Enkephalinergic modulation of non-cholinergic transmission in mammalian prevertebral ganglia",

abstract = "The non-cholinergic excitatory potential elicited in neurons of the isolated inferior mesentric ganglia was depressed by bath application of Met- and Leu-enkephalin and enhanced by naloxone or naltrexone. The membrane depolarization induced by exogenously applied putative transmitter substance P was not appreciably affected by either enkephalin (Enk) or opiate antagonists. Our results indicate that the non-cholinergic excitatory transmission which may be mediated by substance P in prevertebral ganglia is modulated presynaptically by endogenously released Enk in a manner that may resemble the interaction between these two peptides in the spinal cord.",

keywords = "enkephalin, presynaptic modulation, substance P",

author = "Jiang, {Z. G.} and Simmons, {M. A.} and Dun, {N. J.}",

note = "Funding Information: We wish to thank Dr. S. A. Shefner for helpful discussion. This study was supported in part by NIH Grant NS15848.",

year = "1982",

month = mar,

day = "4",

doi = "10.1016/0006-8993(82)90211-6",

language = "English (US)",

volume = "235",

pages = "185--191",

journal = "Brain Research",

issn = "0006-8993",

publisher = "Elsevier",

number = "1",

}

TY - JOUR

T1 - Enkephalinergic modulation of non-cholinergic transmission in mammalian prevertebral ganglia

AU - Jiang, Z. G.

AU - Simmons, M. A.

AU - Dun, N. J.

N1 - Funding Information: We wish to thank Dr. S. A. Shefner for helpful discussion. This study was supported in part by NIH Grant NS15848.

PY - 1982/3/4

Y1 - 1982/3/4

N2 - The non-cholinergic excitatory potential elicited in neurons of the isolated inferior mesentric ganglia was depressed by bath application of Met- and Leu-enkephalin and enhanced by naloxone or naltrexone. The membrane depolarization induced by exogenously applied putative transmitter substance P was not appreciably affected by either enkephalin (Enk) or opiate antagonists. Our results indicate that the non-cholinergic excitatory transmission which may be mediated by substance P in prevertebral ganglia is modulated presynaptically by endogenously released Enk in a manner that may resemble the interaction between these two peptides in the spinal cord.

AB - The non-cholinergic excitatory potential elicited in neurons of the isolated inferior mesentric ganglia was depressed by bath application of Met- and Leu-enkephalin and enhanced by naloxone or naltrexone. The membrane depolarization induced by exogenously applied putative transmitter substance P was not appreciably affected by either enkephalin (Enk) or opiate antagonists. Our results indicate that the non-cholinergic excitatory transmission which may be mediated by substance P in prevertebral ganglia is modulated presynaptically by endogenously released Enk in a manner that may resemble the interaction between these two peptides in the spinal cord.

KW - enkephalin

KW - presynaptic modulation

KW - substance P

UR - http://www.scopus.com/inward/record.url?scp=0020038027&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020038027&partnerID=8YFLogxK

U2 - 10.1016/0006-8993(82)90211-6

DO - 10.1016/0006-8993(82)90211-6

M3 - Article

C2 - 6203600

AN - SCOPUS:0020038027

SN - 0006-8993

VL - 235

SP - 185

EP - 191

JO - Brain Research

JF - Brain Research

IS - 1

ER -

Enkephalinergic modulation of non-cholinergic transmission in mammalian prevertebral ganglia

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this