Enkephalinergic modulation of non-cholinergic transmission in mammalian prevertebral ganglia

Z. G. Jiang, M. A. Simmons, N. J. Dun

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


The non-cholinergic excitatory potential elicited in neurons of the isolated inferior mesentric ganglia was depressed by bath application of Met- and Leu-enkephalin and enhanced by naloxone or naltrexone. The membrane depolarization induced by exogenously applied putative transmitter substance P was not appreciably affected by either enkephalin (Enk) or opiate antagonists. Our results indicate that the non-cholinergic excitatory transmission which may be mediated by substance P in prevertebral ganglia is modulated presynaptically by endogenously released Enk in a manner that may resemble the interaction between these two peptides in the spinal cord.

Original languageEnglish (US)
Pages (from-to)185-191
Number of pages7
JournalBrain research
Issue number1
StatePublished - Mar 4 1982
Externally publishedYes


  • enkephalin
  • presynaptic modulation
  • substance P

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology


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