Enlarged perivascular spaces are not associated with vascular co-morbidities, clinical outcomes, and brain volumes in people with secondary progressive multiple sclerosis

Lindsey Wooliscroft; Erin Boespflug; Andrea Hildebrand; Kathleen Shangraw; Elizabeth Silbermann; Dennis Bourdette; Rebecca Spain

doi:10.1177/2055217320964502

Enlarged perivascular spaces are not associated with vascular co-morbidities, clinical outcomes, and brain volumes in people with secondary progressive multiple sclerosis

Lindsey Wooliscroft
, Erin Boespflug
, Andrea Hildebrand
, Kathleen Shangraw
, Elizabeth Silbermann
, Dennis Bourdette
, Rebecca Spain

Neurology

Research output: Contribution to journal › Article › peer-review

Abstract

Background: In secondary progressive multiple sclerosis (SPMS) significance of enlarged perivascular spaces (ePVS) is unknown. Objectives, Methods: Analysis of associations between vascular co-morbidities, clinical outcomes, and volumetrics with categorical ePVS scores in midbrain, basal ganglia (BG), and centrum semiovale (CSO) in SPMS(n-46). Results, Conclusion: In BG, advancing age (Z = 2.68) and lower Expanded Disability Status Scale (Z = −2.04) were associated with increasing ePVS score. In CSO, advancing age (Z = 2.66) and male gender (Z = 2.45) were associated with increasing ePVS score. No associations between ePVS score and vascular co-morbidities or volumetrics existed; ePVS may not be an informative marker for SPMS.

Original language	English (US)
Journal	Multiple Sclerosis Journal - Experimental, Translational and Clinical
Volume	6
Issue number	4
DOIs	https://doi.org/10.1177/2055217320964502
State	Published - 2020

Funding

The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the Department of Veterans Affairs (B7493-W, R. Spain), NIH (UL1TR000128). Dr. Wooliscroft is supported by K23HD101667 from the National Institutes of Health (NIH). Dr. Silbermann is supported by NMSS Sylvia Lawry Fellowship. Dr. Boespflug was supported by K01AG059842 and P30AG008017 from the NIH.

Keywords

atrophy
biomarkers
MRI
multiple sclerosis
outcome measurement
progressive

ASJC Scopus subject areas

Clinical Neurology
Cellular and Molecular Neuroscience

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10.1177/2055217320964502

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Wooliscroft, L., Boespflug, E., Hildebrand, A., Shangraw, K., Silbermann, E., Bourdette, D., & Spain, R. (2020). Enlarged perivascular spaces are not associated with vascular co-morbidities, clinical outcomes, and brain volumes in people with secondary progressive multiple sclerosis. Multiple Sclerosis Journal - Experimental, Translational and Clinical, 6(4). https://doi.org/10.1177/2055217320964502

Enlarged perivascular spaces are not associated with vascular co-morbidities, clinical outcomes, and brain volumes in people with secondary progressive multiple sclerosis. / Wooliscroft, Lindsey; Boespflug, Erin; Hildebrand, Andrea et al.
In: Multiple Sclerosis Journal - Experimental, Translational and Clinical, Vol. 6, No. 4, 2020.

Research output: Contribution to journal › Article › peer-review

Wooliscroft, L, Boespflug, E, Hildebrand, A, Shangraw, K, Silbermann, E, Bourdette, D & Spain, R 2020, 'Enlarged perivascular spaces are not associated with vascular co-morbidities, clinical outcomes, and brain volumes in people with secondary progressive multiple sclerosis', Multiple Sclerosis Journal - Experimental, Translational and Clinical, vol. 6, no. 4. https://doi.org/10.1177/2055217320964502

Wooliscroft L, Boespflug E, Hildebrand A, Shangraw K, Silbermann E, Bourdette D et al. Enlarged perivascular spaces are not associated with vascular co-morbidities, clinical outcomes, and brain volumes in people with secondary progressive multiple sclerosis. Multiple Sclerosis Journal - Experimental, Translational and Clinical. 2020;6(4). doi: 10.1177/2055217320964502

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abstract = "Background: In secondary progressive multiple sclerosis (SPMS) significance of enlarged perivascular spaces (ePVS) is unknown. Objectives, Methods: Analysis of associations between vascular co-morbidities, clinical outcomes, and volumetrics with categorical ePVS scores in midbrain, basal ganglia (BG), and centrum semiovale (CSO) in SPMS(n-46). Results, Conclusion: In BG, advancing age (Z = 2.68) and lower Expanded Disability Status Scale (Z = −2.04) were associated with increasing ePVS score. In CSO, advancing age (Z = 2.66) and male gender (Z = 2.45) were associated with increasing ePVS score. No associations between ePVS score and vascular co-morbidities or volumetrics existed; ePVS may not be an informative marker for SPMS.",

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author = "Lindsey Wooliscroft and Erin Boespflug and Andrea Hildebrand and Kathleen Shangraw and Elizabeth Silbermann and Dennis Bourdette and Rebecca Spain",

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AU - Hildebrand, Andrea

AU - Shangraw, Kathleen

AU - Silbermann, Elizabeth

AU - Bourdette, Dennis

AU - Spain, Rebecca

N1 - Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the Department of Veterans Affairs (B7493-W, R. Spain), NIH (UL1TR000128). Dr. Wooliscroft is supported by K23HD101667 from the National Institutes of Health (NIH). Dr. Silbermann is supported by NMSS Sylvia Lawry Fellowship. Dr. Boespflug was supported by K01AG059842 and P30AG008017 from the NIH.

PY - 2020

Y1 - 2020

N2 - Background: In secondary progressive multiple sclerosis (SPMS) significance of enlarged perivascular spaces (ePVS) is unknown. Objectives, Methods: Analysis of associations between vascular co-morbidities, clinical outcomes, and volumetrics with categorical ePVS scores in midbrain, basal ganglia (BG), and centrum semiovale (CSO) in SPMS(n-46). Results, Conclusion: In BG, advancing age (Z = 2.68) and lower Expanded Disability Status Scale (Z = −2.04) were associated with increasing ePVS score. In CSO, advancing age (Z = 2.66) and male gender (Z = 2.45) were associated with increasing ePVS score. No associations between ePVS score and vascular co-morbidities or volumetrics existed; ePVS may not be an informative marker for SPMS.

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Enlarged perivascular spaces are not associated with vascular co-morbidities, clinical outcomes, and brain volumes in people with secondary progressive multiple sclerosis

Abstract

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Keywords

ASJC Scopus subject areas

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