Enteral macronutrients abolish high blood alcohol levels in chronic alcoholic rats

Hariharan Sankaran, Georgia C. Baba, Clifford W. Deveney, G. Ananda Rao

Research output: Contribution to journalArticlepeer-review


Rats fed the Lieber-DeCarli 36% alcohol diet ad libitum exhibit alcoholemia. Since 36% of carbohydrate (CHO) calories in the control diet are replaced with alcohol, the alcoholic rats ingest low levels of CHO. Furthermore, alcoholic rats ingest 40-50% less calories when compared to rats fed the control diet ad libitum. The present study was carried out to determine the effect of providing marginal additional energy on blood alcohol levels (BAL) in alcoholic rats. Four groups of rats implanted with intragastric cannulae were allowed to ingest orally the alcohol diet ad libitum, and either water (two control groups, one each for CHO and protein) or additional calories, as either maltose-dextrin or casein, were continously infused through the cannulae. All four groups of rats consumed similar amounts of alcohol; however, water-infused rats exhibited high BAL. The BAL in the two nutrient-infused groups were insignificant. These data demonstrate that BAL can be regulated by nutritional means in rats consuming doses of alcohol high enough to cause alcoholemia.

Original languageEnglish (US)
Pages (from-to)217-222
Number of pages6
JournalNutrition Research
Issue number2-3
StatePublished - 1991


  • Intragastric infusion
  • blood alcohol levels
  • liquid alcohol diet
  • macronutrients
  • nutritional adequacy

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics


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