TY - JOUR
T1 - Epidemiology of Sudden Cardiac Death
T2 - Clinical and Research Implications
AU - Chugh, Sumeet S.
AU - Reinier, Kyndaron
AU - Teodorescu, Carmen
AU - Evanado, Audrey
AU - Kehr, Elizabeth
AU - Al Samara, Mershed
AU - Mariani, Ronald
AU - Gunson, Karen
AU - Jui, Jonathan
N1 - Funding Information:
This work was funded by grant R01HL088416 from the National Heart Lung and Blood Institute (Bethesda, Maryland) and a Hopkins-Reynolds Clinical Cardiovascular Research Center Grant (Las Vegas, Nevada) to Dr Sumeet S. Chugh.
PY - 2008/11
Y1 - 2008/11
N2 - The current annual incidence of sudden cardiac death in the United States is likely to be in the range of 180 000 to 250 000 per year. Coinciding with the decreased mortality from coronary artery disease, there is evidence pointing toward a significant decrease in rates of sudden cardiac death in the United States during the second half of the 20th century. However, the alarming rise in prevalence of obesity and diabetes in the first decade of the new millennium both in the United States and worldwide, would indicate that this favorable trend is unlikely to persist. We are likely to witness a resurgence of coronary artery disease and heart failure, as a result of which sudden cardiac death will have to be confronted as a shared and indiscriminate, worldwide public health problem. There is also increasing recognition of the fact that discovery of meaningful and relevant risk stratification and prevention methodologies will require careful prospective community-wide analyses, with access to large archives of DNA, serum, and tissue that link with well-phenotyped databases. The purpose of this review is to summarize current knowledge of sudden cardiac death epidemiology. We will discuss the significance and strengths of community-wide evaluations of sudden cardiac death, summarize recent observations from such studies, and finally highlight specific potential predictors that warrant further evaluation as determinants of sudden cardiac death in the general population.
AB - The current annual incidence of sudden cardiac death in the United States is likely to be in the range of 180 000 to 250 000 per year. Coinciding with the decreased mortality from coronary artery disease, there is evidence pointing toward a significant decrease in rates of sudden cardiac death in the United States during the second half of the 20th century. However, the alarming rise in prevalence of obesity and diabetes in the first decade of the new millennium both in the United States and worldwide, would indicate that this favorable trend is unlikely to persist. We are likely to witness a resurgence of coronary artery disease and heart failure, as a result of which sudden cardiac death will have to be confronted as a shared and indiscriminate, worldwide public health problem. There is also increasing recognition of the fact that discovery of meaningful and relevant risk stratification and prevention methodologies will require careful prospective community-wide analyses, with access to large archives of DNA, serum, and tissue that link with well-phenotyped databases. The purpose of this review is to summarize current knowledge of sudden cardiac death epidemiology. We will discuss the significance and strengths of community-wide evaluations of sudden cardiac death, summarize recent observations from such studies, and finally highlight specific potential predictors that warrant further evaluation as determinants of sudden cardiac death in the general population.
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U2 - 10.1016/j.pcad.2008.06.003
DO - 10.1016/j.pcad.2008.06.003
M3 - Review article
C2 - 19026856
AN - SCOPUS:56249099670
SN - 0033-0620
VL - 51
SP - 213
EP - 228
JO - Progress in Cardiovascular Diseases
JF - Progress in Cardiovascular Diseases
IS - 3
ER -