Epsins in vascular development, function and disease

Sudarshan Bhattacharjee, Yang Lee, Bo Zhu, Hao Wu, Yabing Chen, Hong Chen

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations

Abstract

Epsins are a family of adaptor proteins involved in clathrin-dependent endocytosis. In the vasculature, epsins 1 and 2 are functionally redundant members of this family that are expressed in the endothelial cells of blood vessels and the lymphatic system throughout development and adulthood. These proteins contain a number of peptide motifs that allow them to interact with lipid moieties and a variety of proteins. These interactions facilitate the regulation of a wide range of cell signaling pathways. In this review, we focus on the involvement of epsins 1 and 2 in controlling vascular endothelial growth factor receptor signaling in angiogenesis and lymphangiogenesis. We also discuss the therapeutic implications of understanding the molecular mechanisms of epsin-mediated regulation in diseases such as atherosclerosis and diabetes.

Original languageEnglish (US)
Pages (from-to)833-842
Number of pages10
JournalCellular and Molecular Life Sciences
Volume78
Issue number3
DOIs
StatePublished - Feb 2021
Externally publishedYes

Keywords

  • Angiogenesis
  • Atherosclerosis
  • Cell signaling
  • Diabetes
  • Endocytic adaptor proteins
  • Endocytosis
  • Inflammatory signaling
  • Lymphangiogenesis
  • Receptor trafficking
  • Vascular endothelial growth factor
  • Vasculogenesis

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Cellular and Molecular Neuroscience
  • Cell Biology

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