Abstract
Epsins are a family of adaptor proteins involved in clathrin-dependent endocytosis. In the vasculature, epsins 1 and 2 are functionally redundant members of this family that are expressed in the endothelial cells of blood vessels and the lymphatic system throughout development and adulthood. These proteins contain a number of peptide motifs that allow them to interact with lipid moieties and a variety of proteins. These interactions facilitate the regulation of a wide range of cell signaling pathways. In this review, we focus on the involvement of epsins 1 and 2 in controlling vascular endothelial growth factor receptor signaling in angiogenesis and lymphangiogenesis. We also discuss the therapeutic implications of understanding the molecular mechanisms of epsin-mediated regulation in diseases such as atherosclerosis and diabetes.
Original language | English (US) |
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Pages (from-to) | 833-842 |
Number of pages | 10 |
Journal | Cellular and Molecular Life Sciences |
Volume | 78 |
Issue number | 3 |
DOIs | |
State | Published - Feb 2021 |
Externally published | Yes |
Keywords
- Angiogenesis
- Atherosclerosis
- Cell signaling
- Diabetes
- Endocytic adaptor proteins
- Endocytosis
- Inflammatory signaling
- Lymphangiogenesis
- Receptor trafficking
- Vascular endothelial growth factor
- Vasculogenesis
ASJC Scopus subject areas
- Molecular Medicine
- Molecular Biology
- Pharmacology
- Cellular and Molecular Neuroscience
- Cell Biology