TY - JOUR
T1 - Esophageal motility
AU - Fennerty, M. Brian
AU - Garewal, Harinder S.
PY - 1996
Y1 - 1996
N2 - Nitric oxide, the nonandrenergic, noncholingergic neurotransmitter, appears to be the inhibitory neurotransmitter that effects lower esophageal sphincter relaxation. Perturbations in this neurotransmitter axis may be responsible for diseases associated with lower esophageal sphincter dysfunction leg, gastroesophageal reflux disease, achalasia). It is likely that efforts directed at correcting the perturbation in nitric oxide effect will result in novel treatments for these diseases. As increasing options for treatment of achalasia become available, the optimal approach to therapy may finally be realized. Appropriate economic models will need to be developed, because it is unlikely that long-term controlled clinical trials comparing surgical therapy with endoscopic or pharmacologic therapy will be performed. Finally, dysfunction of the upper esophageal sphincter is being increasingly recognized; however, appropriate evaluation, treatment, and natural history of these disorders are as yet unknown.
AB - Nitric oxide, the nonandrenergic, noncholingergic neurotransmitter, appears to be the inhibitory neurotransmitter that effects lower esophageal sphincter relaxation. Perturbations in this neurotransmitter axis may be responsible for diseases associated with lower esophageal sphincter dysfunction leg, gastroesophageal reflux disease, achalasia). It is likely that efforts directed at correcting the perturbation in nitric oxide effect will result in novel treatments for these diseases. As increasing options for treatment of achalasia become available, the optimal approach to therapy may finally be realized. Appropriate economic models will need to be developed, because it is unlikely that long-term controlled clinical trials comparing surgical therapy with endoscopic or pharmacologic therapy will be performed. Finally, dysfunction of the upper esophageal sphincter is being increasingly recognized; however, appropriate evaluation, treatment, and natural history of these disorders are as yet unknown.
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U2 - 10.1097/00001574-199607000-00011
DO - 10.1097/00001574-199607000-00011
M3 - Review article
AN - SCOPUS:0029838451
SN - 0267-1379
VL - 12
SP - 373
EP - 379
JO - Current Opinion in Gastroenterology
JF - Current Opinion in Gastroenterology
IS - 4
ER -