Esophagectomy as a treatment consideration for early-stage esophageal cancer and high-grade dysplasia

Patrick J. McLaren, James P. Dolan

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


In recent years, a number of endoluminal procedures such as endoscopic resection and thermal ablation have emerged as less invasive treatment options for early esophageal cancer. These therapies have demonstrated excellent oncologic outcomes for dysplasia as well as intramucosal cancers. However, few studies have directly compared long-term outcomes of endoscopic therapy versus traditional esophagectomy. Current esophagectomy techniques now deliver consistently good outcomes in the hands of experienced surgeons at high volume centers, and this option should be considered an important treatment consideration for early esophageal cancer. Under current recommendations, esophagectomy should be considered for tumors invading the submucosa, tumors with high-risk pathologic features, bulky tumors, multinodular tumors, tumors within a long segment of Barrett's esophagus, and tumors adjacent to a hiatal hernia. Likewise, individual patient factors and comorbidities must also be considered when determining the best treatment for a patient with early esophageal cancer. The risk of missing metastatic disease or recurrence that is associated with endoscopic treatment must be weighed against the surgical risks of esophagectomy. With these considerations in mind, the aim of this article is to review the current guidelines and literature that explore the role of esophagectomy for early esophageal malignancy in the era of endoscopic therapies.

Original languageEnglish (US)
Pages (from-to)757-762
Number of pages6
JournalJournal of Laparoendoscopic and Advanced Surgical Techniques
Issue number10
StatePublished - Oct 2016


  • endoscopic resection
  • esophageal cancer
  • esophagectomy
  • high grade dysplasia
  • intramucosal cancer
  • oesophageal cancer

ASJC Scopus subject areas

  • Surgery


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