Essential roles in synaptic plasticity for synaptogyrin I and synaptophysin I

Roger Janz, Thomas C. Südhof, Robert E. Hammer, Vivek Unni, Steven A. Siegelbaum, Vadim Y. Bolshakov

Research output: Contribution to journalArticlepeer-review

275 Scopus citations


We have generated mice lacking synaptogyrin I and synaptophysin I to explore the functions of these abundant tyrosine-phosphorylated proteins of synaptic vesicles. Single and double knockout mice were alive and fertile without significant morphological or biochemical changes. Electrophysiological recordings in the hippocampal CA1 region revealed that short-term and long-term synaptic plasticity were severely reduced in the synaptophysin/synaptogyrin double knockout mice. LTP was decreased independent of the induction protocol, suggesting that the defect in LTP was not caused by insufficient induction. Our data show that synaptogyrin I and synaptophysin I perform redundant and essential functions in synaptic plasticity without being required for neurotransmitter release itself.

Original languageEnglish (US)
Pages (from-to)687-700
Number of pages14
Issue number3
StatePublished - Nov 1999
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)


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