Ethanol and the NMDA receptor

Paula L. Hoffman; Carolyn S. Rabe; Kathleen A. Grant; Peter Valverius; Michael Hudspith; Boris Tabakoff

doi:10.1016/0741-8329(90)90010-A

Ethanol and the NMDA receptor

Paula L. Hoffman, Carolyn S. Rabe, Kathleen A. Grant, Peter Valverius, Michael Hudspith, Boris Tabakoff

Research output: Contribution to journal › Article › peer-review

119 Scopus citations

Abstract

The actions of glutamate, the major excitatory amino acid in the CNS, are mediated by three receptor subtypes: kainate, quisqualate and N-methyl-D-aspartate (NMDA) receptors. Ethanol, in vitro, is a potent and selective inhibitor of the actions of agonists at the NMDA receptor. Following chronic ethanol ingestion, the number of NMDA receptor-ion channel complexes in certain brain areas is increased. This increase may contribute to the generation of ethanol withdrawal seizures, since administration of an NMDA receptor antagonist can reduce these seizures. The results suggest that certain acute behavioral effects of ethanol, such as effects on memory, as well as certain aspects of ethanol withdrawal, may involve the NMDA receptor.

Original language	English (US)
Pages (from-to)	229-231
Number of pages	3
Journal	Alcohol
Volume	7
Issue number	3
DOIs	https://doi.org/10.1016/0741-8329(90)90010-A
State	Published - 1990
Externally published	Yes

Keywords

Calcium influx
Cyclic GMP
Ethanol
Ethanol withdrawal seizures
Glutamate
MK-801 binding
NMDA receptor

ASJC Scopus subject areas

Health(social science)
Biochemistry
Toxicology
Neurology
Behavioral Neuroscience

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10.1016/0741-8329(90)90010-A

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title = "Ethanol and the NMDA receptor",

abstract = "The actions of glutamate, the major excitatory amino acid in the CNS, are mediated by three receptor subtypes: kainate, quisqualate and N-methyl-D-aspartate (NMDA) receptors. Ethanol, in vitro, is a potent and selective inhibitor of the actions of agonists at the NMDA receptor. Following chronic ethanol ingestion, the number of NMDA receptor-ion channel complexes in certain brain areas is increased. This increase may contribute to the generation of ethanol withdrawal seizures, since administration of an NMDA receptor antagonist can reduce these seizures. The results suggest that certain acute behavioral effects of ethanol, such as effects on memory, as well as certain aspects of ethanol withdrawal, may involve the NMDA receptor.",

keywords = "Calcium influx, Cyclic GMP, Ethanol, Ethanol withdrawal seizures, Glutamate, MK-801 binding, NMDA receptor",

author = "Hoffman, {Paula L.} and Rabe, {Carolyn S.} and Grant, {Kathleen A.} and Peter Valverius and Michael Hudspith and Boris Tabakoff",

year = "1990",

doi = "10.1016/0741-8329(90)90010-A",

language = "English (US)",

volume = "7",

pages = "229--231",

journal = "Alcohol",

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publisher = "Elsevier Inc.",

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T1 - Ethanol and the NMDA receptor

AU - Hoffman, Paula L.

AU - Rabe, Carolyn S.

AU - Grant, Kathleen A.

AU - Valverius, Peter

AU - Hudspith, Michael

AU - Tabakoff, Boris

PY - 1990

Y1 - 1990

N2 - The actions of glutamate, the major excitatory amino acid in the CNS, are mediated by three receptor subtypes: kainate, quisqualate and N-methyl-D-aspartate (NMDA) receptors. Ethanol, in vitro, is a potent and selective inhibitor of the actions of agonists at the NMDA receptor. Following chronic ethanol ingestion, the number of NMDA receptor-ion channel complexes in certain brain areas is increased. This increase may contribute to the generation of ethanol withdrawal seizures, since administration of an NMDA receptor antagonist can reduce these seizures. The results suggest that certain acute behavioral effects of ethanol, such as effects on memory, as well as certain aspects of ethanol withdrawal, may involve the NMDA receptor.

AB - The actions of glutamate, the major excitatory amino acid in the CNS, are mediated by three receptor subtypes: kainate, quisqualate and N-methyl-D-aspartate (NMDA) receptors. Ethanol, in vitro, is a potent and selective inhibitor of the actions of agonists at the NMDA receptor. Following chronic ethanol ingestion, the number of NMDA receptor-ion channel complexes in certain brain areas is increased. This increase may contribute to the generation of ethanol withdrawal seizures, since administration of an NMDA receptor antagonist can reduce these seizures. The results suggest that certain acute behavioral effects of ethanol, such as effects on memory, as well as certain aspects of ethanol withdrawal, may involve the NMDA receptor.

KW - Calcium influx

KW - Cyclic GMP

KW - Ethanol

KW - Ethanol withdrawal seizures

KW - Glutamate

KW - MK-801 binding

KW - NMDA receptor

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DO - 10.1016/0741-8329(90)90010-A

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JO - Alcohol

JF - Alcohol

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Ethanol and the NMDA receptor

Abstract

Keywords

ASJC Scopus subject areas

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