Ethanol dependence and the pituitary-adrenal axis in mice I. Genotypic differences in hormone levels.

John C. Crabbe; L. Donald Keith; Ann Kosobud; Julianne Stack

doi:10.1016/0024-3205(83)90672-0

Ethanol dependence and the pituitary-adrenal axis in mice I. Genotypic differences in hormone levels.

John C. Crabbe, L. Donald Keith, Ann Kosobud, Julianne Stack

Behavioral Neuroscience

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23 Scopus citations

Abstract

Resting pituitary levels of β-endorphin-(β-EP-IR), ACTH-(ACTH-IR), and α-MSH-(α-MSH-IR)-like immunoreactive material were found to differ among 16 inbred mouse strains. Hormone levels correlated genetically with severity of withdrawal from ethanol, which also differed among the strains. Ethanol dependence led to reduced pituitary β-EP-IR in 4 of 5 strains studied. After 24 hr of withdrawal, 3 of those 4 showed elevated pituitary β-EP-IR. These results are consistent with the hypothesis that genetically-determined difference in pituitary hormone functioning underlie some of the genetically-determined differences in ethanol withdrawal severity.

Original language	English (US)
Pages (from-to)	1877-1887
Number of pages	11
Journal	Life Sciences
Volume	33
Issue number	19
DOIs	https://doi.org/10.1016/0024-3205(83)90672-0
State	Published - Nov 7 1983

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Pharmacology, Toxicology and Pharmaceutics(all)

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10.1016/0024-3205(83)90672-0

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abstract = "Resting pituitary levels of β-endorphin-(β-EP-IR), ACTH-(ACTH-IR), and α-MSH-(α-MSH-IR)-like immunoreactive material were found to differ among 16 inbred mouse strains. Hormone levels correlated genetically with severity of withdrawal from ethanol, which also differed among the strains. Ethanol dependence led to reduced pituitary β-EP-IR in 4 of 5 strains studied. After 24 hr of withdrawal, 3 of those 4 showed elevated pituitary β-EP-IR. These results are consistent with the hypothesis that genetically-determined difference in pituitary hormone functioning underlie some of the genetically-determined differences in ethanol withdrawal severity.",

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AU - Stack, Julianne

PY - 1983/11/7

Y1 - 1983/11/7

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AB - Resting pituitary levels of β-endorphin-(β-EP-IR), ACTH-(ACTH-IR), and α-MSH-(α-MSH-IR)-like immunoreactive material were found to differ among 16 inbred mouse strains. Hormone levels correlated genetically with severity of withdrawal from ethanol, which also differed among the strains. Ethanol dependence led to reduced pituitary β-EP-IR in 4 of 5 strains studied. After 24 hr of withdrawal, 3 of those 4 showed elevated pituitary β-EP-IR. These results are consistent with the hypothesis that genetically-determined difference in pituitary hormone functioning underlie some of the genetically-determined differences in ethanol withdrawal severity.

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Ethanol dependence and the pituitary-adrenal axis in mice I. Genotypic differences in hormone levels.

Abstract

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